Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Potentiation of acetaminophen hepatotoxicity by phenytoin, leading to liver transplantation.

Literature DB >> 16187183

Potentiation of acetaminophen hepatotoxicity by phenytoin, leading to liver transplantation.

Scott M Suchin¹, David C Wolf, Young Lee, Gita Ramaswamy, Patricia A Sheiner, Marcelo Facciuto, Michael R Marvin, Leona Kim-Schluger, Edward Lebovics.

Abstract

We report the case of a 22-year-old man who developed fulminant hepatic failure 3 days after an intentional acetaminophen overdose. The patient had a history of a seizure disorder for which he was taking phenytoin. The acetaminophen level at presentation was in the "nontoxic" range. Emergent liver transplantation was performed 4 days after the ingestion. This is the first reported case of successful liver transplantation for acetaminophen-induced fulminant hepatic failure in the setting of phenytoin therapy.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2005 PMID： 16187183 DOI： 10.1007/s10620-005-2947-4

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

7 in total

1. Acetaminophen poisoning and toxicity.

Authors: B H Rumack; H Matthew
Journal: Pediatrics Date: 1975-06 Impact factor: 7.124

2. Management of paracetamol poisoning complicated by enzyme induction due to alcohol or drugs.

Authors: B M McClements; M Hyland; M E Callender; T L Blair
Journal: Lancet Date: 1990-06-23 Impact factor: 79.321

3. Fatal paracetamol poisoning in an epileptic.

Authors: N A Minton; J A Henry; R J Frankel
Journal: Hum Toxicol Date: 1988-01

4. Acetaminophen hepatotoxicity: the first 35 years.

Authors: Barry H Rumack
Journal: J Toxicol Clin Toxicol Date: 2002

5. Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure.

Authors: G P Bray; P M Harrison; J G O'Grady; J M Tredger; R Williams
Journal: Hum Exp Toxicol Date: 1992-07 Impact factor: 2.903

6. Paracetamol disposition in normal subjects and in patients treated with antiepileptic drugs.

Authors: E Perucca; A Richens
Journal: Br J Clin Pharmacol Date: 1979-02 Impact factor: 4.335

7. Etiology and outcome for 295 patients with acute liver failure in the United States.

Authors: F V Schiodt; E Atillasoy; A O Shakil; E R Schiff; C Caldwell; K V Kowdley; R Stribling; J S Crippin; S Flamm; K A Somberg; H Rosen; T M McCashland; J E Hay; W M Lee
Journal: Liver Transpl Surg Date: 1999-01

7 in total

4 in total

Potentiation of acetaminophen hepatotoxicity by phenytoin, leading to liver transplantation.

1. Acetaminophen poisoning and toxicity.

2. Management of paracetamol poisoning complicated by enzyme induction due to alcohol or drugs.

3. Fatal paracetamol poisoning in an epileptic.

4. Acetaminophen hepatotoxicity: the first 35 years.

5. Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure.

6. Paracetamol disposition in normal subjects and in patients treated with antiepileptic drugs.

7. Etiology and outcome for 295 patients with acute liver failure in the United States.

1. Phenytoin-potentiated hepatotoxicity following acetaminophen overdose? A closer look.

Review 2. Gastrointestinal Side Effects of Antiarrhythmic Medications: A Review of Current Literature.

Review 3. Does cytochrome P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose?

4. The Risk of Drug-Drug Interactions with Paracetamol in a Population of Hospitalized Geriatric Patients.