OBJECTIVE: The authors evaluated the relation between maternal pregnancy loss, birth characteristics, and childhood leukemia in the Northern California Childhood Leukemia Study. METHODS: Incident cases of childhood leukemia (age 0-14 years) were rapidly ascertained, and controls were randomly selected from birth records and individually matched to cases. A total of 366 cases [313 acute lymphoblastic leukemia (ALL) and 53 acute myeloid leukemia (AML)] and 460 controls were included in this analysis. The biological mothers of all subjects provided detailed reproductive history and birth characteristics of the index children during a personal interview. Odds ratio (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Data on maternal pregnancy loss and birth characteristics were also available from the birth certificates of 96.3% of all subjects. RESULTS: History of miscarriage was associated with a significantly increased risk of AML (OR = 2.94, 95% CI: 1.03, 8.34), but not ALL. Neither birth weight, birth order, or parental ages appeared to be an important predictor of the risk of ALL or AML. A comparison between data from two different sources (interview versus birth certificate) indicated good reproducibility and offered some evidence against recall bias. CONCLUSION: Maternal history of miscarriage is associated with an increased risk of childhood AML.
OBJECTIVE: The authors evaluated the relation between maternal pregnancy loss, birth characteristics, and childhood leukemia in the Northern California Childhood Leukemia Study. METHODS: Incident cases of childhood leukemia (age 0-14 years) were rapidly ascertained, and controls were randomly selected from birth records and individually matched to cases. A total of 366 cases [313 acute lymphoblastic leukemia (ALL) and 53 acute myeloid leukemia (AML)] and 460 controls were included in this analysis. The biological mothers of all subjects provided detailed reproductive history and birth characteristics of the index children during a personal interview. Odds ratio (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Data on maternal pregnancy loss and birth characteristics were also available from the birth certificates of 96.3% of all subjects. RESULTS: History of miscarriage was associated with a significantly increased risk of AML (OR = 2.94, 95% CI: 1.03, 8.34), but not ALL. Neither birth weight, birth order, or parental ages appeared to be an important predictor of the risk of ALL or AML. A comparison between data from two different sources (interview versus birth certificate) indicated good reproducibility and offered some evidence against recall bias. CONCLUSION: Maternal history of miscarriage is associated with an increased risk of childhood AML.
Authors: Kevin Y Urayama; Xiaomei Ma; Steve Selvin; Catherine Metayer; Anand P Chokkalingam; Joseph L Wiemels; Monique Does; Jeffrey Chang; Alan Wong; Elizabeth Trachtenberg; Patricia A Buffler Journal: Int J Cancer Date: 2010-12-17 Impact factor: 7.396
Authors: Julie Von Behren; Logan G Spector; Beth A Mueller; Susan E Carozza; Eric J Chow; Erin E Fox; Scott Horel; Kimberly J Johnson; Colleen McLaughlin; Susan E Puumala; Julie A Ross; Peggy Reynolds Journal: Int J Cancer Date: 2010-10-08 Impact factor: 7.396
Authors: R Marcos-Gragera; J Galceran; C Martos; A L de Munain; M Vicente-Raneda; C Navarro; J R Quirós-Garcia; M-J Sánchez; E Ardanaz; M Ramos; A Mateos; D Salmerón; S Felipe; R Peris-Bonet Journal: Clin Transl Oncol Date: 2016-07-22 Impact factor: 3.405
Authors: Theodoros N Sergentanis; Thomas P Thomopoulos; Spyros P Gialamas; Maria A Karalexi; Stylianos-Iason Biniaris-Georgallis; Evangelia Kontogeorgi; Paraskevi Papathoma; Gerasimos Tsilimidos; Alkistis Skalkidou; Anastasia N Iliadou; Eleni T Petridou Journal: Eur J Epidemiol Date: 2015-11-04 Impact factor: 8.082
Authors: Philip J Lupo; Heather E Danysh; Stephen X Skapek; Douglas S Hawkins; Logan G Spector; Renke Zhou; M Fatih Okcu; Karin Papworth; Erik B Erhardt; Seymour Grufferman Journal: Cancer Causes Control Date: 2014-05-16 Impact factor: 2.506