PURPOSE: Previous assessments of childhood rhabdomyosarcoma have indicated maternal and birth characteristics may be associated with tumor development; however, much work remains to identify novel and confirm suspected risk factors. Our objective was to evaluate the associations between maternal and birth characteristics and childhood rhabdomyosarcoma. METHODS: This case-control study included 322 cases and 322 pair-matched controls. Cases were enrolled in a trial run by the Intergroup Rhabdomyosarcoma Study Group. Population-based controls were identified using random digit dialing and were individually matched to cases on race, sex, and age. Families of the case and control subjects participated in a telephone interview, which captured information on maternal characteristics (birth control use, number of prenatal visits, anemia, and abnormal bleeding during pregnancy) and birth characteristics [birth weight, preterm birth, and type of delivery (vaginal vs. cesarean)]. Conditional logistic regression models were used to calculate an odds ratio (OR) and 95% confidence interval (CI) for each exposure, adjusted for age, race, sex, household income, and parental education. As the two most common histologic types of rhabdomyosarcoma are embryonal (n = 215) and alveolar (n = 66), we evaluated effect heterogeneity of these exposures. RESULTS: The only characteristic that was associated with childhood rhabdomyosarcoma, and statistically significant, was abnormal vaginal bleeding during pregnancy (OR 1.75, 95% CI 1.12-2.74). Birth control use (OR 1.45, 95% CI 0.96-2.18), anemia during pregnancy (OR 1.27, 95% CI 0.81-1.99), and preterm birth (OR 2.51, 95% CI 0.74-8.49) were positively associated with childhood rhabdomyosarcoma, but were not statistically significant. Low birth weight [adjusted odds ratios (aOR) 4.46, 95% CI 1.41-14.1] and high birth weight (aOR 2.41, 95% CI 1.09-5.35) were strongly associated with alveolar rhabdomyosarcoma. However, these factors did not display significant effect heterogeneity between histologic types (p > 0.15 for all characteristics). CONCLUSIONS: Overall, we found little evidence that these maternal and birth characteristics are strongly associated with childhood rhabdomyosarcoma.
PURPOSE: Previous assessments of childhood rhabdomyosarcoma have indicated maternal and birth characteristics may be associated with tumor development; however, much work remains to identify novel and confirm suspected risk factors. Our objective was to evaluate the associations between maternal and birth characteristics and childhood rhabdomyosarcoma. METHODS: This case-control study included 322 cases and 322 pair-matched controls. Cases were enrolled in a trial run by the Intergroup Rhabdomyosarcoma Study Group. Population-based controls were identified using random digit dialing and were individually matched to cases on race, sex, and age. Families of the case and control subjects participated in a telephone interview, which captured information on maternal characteristics (birth control use, number of prenatal visits, anemia, and abnormal bleeding during pregnancy) and birth characteristics [birth weight, preterm birth, and type of delivery (vaginal vs. cesarean)]. Conditional logistic regression models were used to calculate an odds ratio (OR) and 95% confidence interval (CI) for each exposure, adjusted for age, race, sex, household income, and parental education. As the two most common histologic types of rhabdomyosarcoma are embryonal (n = 215) and alveolar (n = 66), we evaluated effect heterogeneity of these exposures. RESULTS: The only characteristic that was associated with childhood rhabdomyosarcoma, and statistically significant, was abnormal vaginal bleeding during pregnancy (OR 1.75, 95% CI 1.12-2.74). Birth control use (OR 1.45, 95% CI 0.96-2.18), anemia during pregnancy (OR 1.27, 95% CI 0.81-1.99), and preterm birth (OR 2.51, 95% CI 0.74-8.49) were positively associated with childhood rhabdomyosarcoma, but were not statistically significant. Low birth weight [adjusted odds ratios (aOR) 4.46, 95% CI 1.41-14.1] and high birth weight (aOR 2.41, 95% CI 1.09-5.35) were strongly associated with alveolar rhabdomyosarcoma. However, these factors did not display significant effect heterogeneity between histologic types (p > 0.15 for all characteristics). CONCLUSIONS: Overall, we found little evidence that these maternal and birth characteristics are strongly associated with childhood rhabdomyosarcoma.
Authors: Greta R Bunin; Logan G Spector; Andrew F Olshan; Leslie L Robison; Michelle Roesler; Seymour Grufferman; Xiao-ou Shu; Julie A Ross Journal: Am J Epidemiol Date: 2007-04-23 Impact factor: 4.897
Authors: Logan G Spector; Susan E Puumala; Susan E Carozza; Eric J Chow; Erin E Fox; Scott Horel; Kimberly J Johnson; Colleen C McLaughlin; Peggy Reynolds; Julie Von Behren; Beth A Mueller Journal: Pediatrics Date: 2009-07 Impact factor: 7.124
Authors: Seymour Grufferman; Frederick Ruymann; Simona Ognjanovic; Erik B Erhardt; Harold M Maurer Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-03-17 Impact factor: 4.254
Authors: Carrie L Williams; Kathryn J Bunch; Charles A Stiller; Michael F G Murphy; Beverley J Botting; W Hamish Wallace; Melanie Davies; Alastair G Sutcliffe Journal: N Engl J Med Date: 2013-11-07 Impact factor: 91.245
Authors: Catalina Ruiz-Mesa; John M Goldberg; Alvaro J Coronado Munoz; Sarah N Dumont; Jonathan C Trent Journal: Curr Treat Options Oncol Date: 2015-06
Authors: Lindsay A Williams; Jeannette Sample; Colleen C McLaughlin; Beth A Mueller; Eric J Chow; Susan E Carozza; Peggy Reynolds; Logan G Spector Journal: Cancer Causes Control Date: 2021-07-23 Impact factor: 2.506
Authors: Hari Sankaran; Heather E Danysh; Michael E Scheurer; M Fatih Okcu; Stephen X Skapek; Douglas S Hawkins; Logan G Spector; Erik B Erhardt; Seymour Grufferman; Philip J Lupo Journal: Pediatr Blood Cancer Date: 2016-05-19 Impact factor: 3.167
Authors: Gerald M Kendall; Kathryn J Bunch; Charles A Stiller; Timothy J Vincent; Michael F G Murphy Journal: Br J Cancer Date: 2020-02-26 Impact factor: 7.640