OBJECTIVE: We studied the effects of beta-carotene (BC) on ventricular remodeling after myocardial infarction. METHODS: Myocardial infarction was induced in Wistar rats that were then treated with a BC diet (500 mg/kg of diet per day; MI-BC; n = 27) or a regular diet (MI; n = 27). Hearts were analyzed in vivo and in vitro after 6 mo. RESULTS: BC caused decreased left ventricular wall thickness (MI = 1.49 +/- 0.3 mm, MI-BC = 1.23 +/- 0.2 mm, P = 0.027) and increased diastolic (MI = 0.83 +/- 0.15 cm2, MI-BC = 0.98 +/- 0.14 cm2, P = 0.020) and systolic (MI = 0.56 +/- 0.12 cm2, MI-BC = 0.75 +/- 0.13 cm2, P = 0.002) left ventricular chamber areas. With respect to systolic function, the BC group presented less change in fractional area than did controls (MI = 32.35 +/- 6.67, MI-BC = 23.77 +/- 6.06, P = 0.004). There was no difference in transmitral diastolic flow velocities between groups. In vitro results showed decreased maximal isovolumetric systolic pressure (MI = 125.5 +/- 24.1 mmHg, MI-BC = 95.2 +/- 28.4 mmHg, P = 0.019) and increased interstitial myocardial collagen concentration (MI = 3.3 +/- 1.2%, MI-BC = 5.8 +/- 1.7%, P = 0.004) in BC-treated animals. Infarct sizes were similar between groups (MI = 45.0 +/- 6.6%, MI-BC = 48.0 +/- 5.8%, P = 0.246). CONCLUSION: Taken together, these data suggest that BC has adverse effects on ventricular remodeling after myocardial infarction.
OBJECTIVE: We studied the effects of beta-carotene (BC) on ventricular remodeling after myocardial infarction. METHODS:Myocardial infarction was induced in Wistar rats that were then treated with a BC diet (500 mg/kg of diet per day; MI-BC; n = 27) or a regular diet (MI; n = 27). Hearts were analyzed in vivo and in vitro after 6 mo. RESULTS:BC caused decreased left ventricular wall thickness (MI = 1.49 +/- 0.3 mm, MI-BC = 1.23 +/- 0.2 mm, P = 0.027) and increased diastolic (MI = 0.83 +/- 0.15 cm2, MI-BC = 0.98 +/- 0.14 cm2, P = 0.020) and systolic (MI = 0.56 +/- 0.12 cm2, MI-BC = 0.75 +/- 0.13 cm2, P = 0.002) left ventricular chamber areas. With respect to systolic function, the BC group presented less change in fractional area than did controls (MI = 32.35 +/- 6.67, MI-BC = 23.77 +/- 6.06, P = 0.004). There was no difference in transmitral diastolic flow velocities between groups. In vitro results showed decreased maximal isovolumetric systolic pressure (MI = 125.5 +/- 24.1 mmHg, MI-BC = 95.2 +/- 28.4 mmHg, P = 0.019) and increased interstitial myocardial collagen concentration (MI = 3.3 +/- 1.2%, MI-BC = 5.8 +/- 1.7%, P = 0.004) in BC-treated animals. Infarct sizes were similar between groups (MI = 45.0 +/- 6.6%, MI-BC = 48.0 +/- 5.8%, P = 0.246). CONCLUSION: Taken together, these data suggest that BC has adverse effects on ventricular remodeling after myocardial infarction.
Authors: Bruna Paola Murino Rafacho; Priscila Portugal Dos Santos; Andréa de Freitas Gonçalves; Ana Angélica Henrique Fernandes; Katashi Okoshi; Fernanda Chiuso-Minicucci; Paula S Azevedo; Leonardo Antonio Mamede Zornoff; Marcos Ferreira Minicucci; Xiang-Dong Wang; Sergio Alberto Rupp de Paiva Journal: PLoS One Date: 2017-05-11 Impact factor: 3.240
Authors: Bruna C Oliveira; Priscila P Santos; Amanda M Figueiredo; Bruna P M Rafacho; Larissa Ishikawa; Silméia G Zanati; Ana A H Fernandes; Paula S Azevedo; Bertha F Polegato; Leonardo A M Zornoff; Marcos F Minicucci; Sergio A R Paiva Journal: Arq Bras Cardiol Date: 2021-06 Impact factor: 2.000