Literature DB >> 16182556

Detection and quantification of 3,5,3'-triiodothyronine and 3,3',5'-triiodothyronine by electrospray ionization tandem mass spectrometry.

Yuntao Zhang1, Abigail H Conrad, Gary W Conrad.   

Abstract

A novel and rapid method for identifying and quantifying 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3; reverse T3) has been introduced using electrospray ionization tandem mass spectrometry (ESI-MS/MS). MS(2) spectra in either negative ionization mode or positive ionization mode can be used to differentiate T3 and rT3. Quantification of the T3 and rT3 isomers under the negative ionization mode is also achieved without prior separation by HPLC.

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Year:  2005        PMID： 16182556     DOI： 10.1016/j.jasms.2005.06.017

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  23 in total

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3.  3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro.

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8.  Cyclosporine metabolite cross-reactivity in different cyclosporine assays.

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  6 in total

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3.  Isomeric discrimination and quantification of thyroid hormones, T3 and rT3, by the single ratio kinetic method using electrospray ionization mass spectrometry.

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Journal:  J Am Soc Mass Spectrom       Date:  2009-07-14       Impact factor: 3.109

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5.  Correlation between Serum Levels of 3,3',5'-Triiodothyronine and Thyroid Hormones Measured by Liquid Chromatography-Tandem Mass Spectrometry and Immunoassay.

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6.  A direct comparison of liquid chromatography-mass spectrometry with clinical routine testing immunoassay methods for the detection and quantification of thyroid hormones in blood serum.

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  6 in total

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