Marie K Hoeger Bement1, Kathleen A Sluka. 1. Physical Therapy Department, Integrative Neuroscience Research Center, College of Health Sciences, Marquette University, Milwaukee, WI 53201, USA. mariehoeger.bement@marquette.edu
Abstract
OBJECTIVE: To determine the effects of low-intensity exercise on chronic muscle pain and potential activation of the endogenous opioid system. DESIGN: Randomized placebo-controlled trial. SETTING: Animal laboratory. ANIMALS: Sixty-three male Sprague-Dawley rats. INTERVENTIONS: Rats performed a low-intensity exercise protocol for 5 consecutive days after the induction of chronic muscle pain. In a separate experiment, naloxone or saline was administered systemically before 5 low-intensity exercise sessions. MAIN OUTCOME MEASURE: Mechanical hyperalgesia was measured using von Frey filaments to determine the mechanical withdrawal threshold. RESULTS: Low-intensity exercise increased mechanical withdrawal threshold in the chronic muscle pain model. Naloxone attenuated the antihyperalgesic effects of low-intensity exercise. CONCLUSIONS: Low-intensity exercise reversed mechanical hyperalgesia in the chronic muscle pain model through activation of the endogenous opioid system.
OBJECTIVE: To determine the effects of low-intensity exercise on chronic muscle pain and potential activation of the endogenous opioid system. DESIGN: Randomized placebo-controlled trial. SETTING: Animal laboratory. ANIMALS: Sixty-three male Sprague-Dawley rats. INTERVENTIONS:Rats performed a low-intensity exercise protocol for 5 consecutive days after the induction of chronic muscle pain. In a separate experiment, naloxone or saline was administered systemically before 5 low-intensity exercise sessions. MAIN OUTCOME MEASURE: Mechanical hyperalgesia was measured using von Frey filaments to determine the mechanical withdrawal threshold. RESULTS: Low-intensity exercise increased mechanical withdrawal threshold in the chronic muscle pain model. Naloxone attenuated the antihyperalgesic effects of low-intensity exercise. CONCLUSIONS: Low-intensity exercise reversed mechanical hyperalgesia in the chronic muscle pain model through activation of the endogenous opioid system.
Authors: Peter M Grace; Timothy J Fabisiak; Suzanne M Green-Fulgham; Nathan D Anderson; Keith A Strand; Andrew J Kwilasz; Erika L Galer; Frederick Rohan Walker; Benjamin N Greenwood; Steven F Maier; Monika Fleshner; Linda R Watkins Journal: Pain Date: 2016-09 Impact factor: 6.961
Authors: Patricia J Ward; April N Herrity; Rebecca R Smith; Andrea Willhite; Benjamin J Harrison; Jeffrey C Petruska; Susan J Harkema; Charles H Hubscher Journal: J Neurotrauma Date: 2014-03-25 Impact factor: 5.269