| Literature DB >> 16180822 |
Jian He1, Ulrich Lion, Isabel Sattler, Friedrich A Gollmick, Susanne Grabley, Jingmin Cai, Marinus Meiners, Henning Schünke, Karsten Schaumann, Ute Dechert, Michael Krohn.
Abstract
From Penicillium janczewskii, obtained from a marine sample, two new diastereomeric quinolinones, 3S,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (1) and 3R,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (2), were identified, along with two known alkaloids, peniprequinolone (3) and 3-methoxy-4-hydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (4). Cytotoxicity testing on eight tumor cell lines revealed a moderate specificity of 2 on SKOV-3 cells.Entities:
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Year: 2005 PMID： 16180822 DOI： 10.1021/np058018g
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050