Literature DB >> 22295903

Aflaquinolones A-G: secondary metabolites from marine and fungicolous isolates of Aspergillus spp.

Scott A Neff1, Sang Un Lee, Yukihiro Asami, Jong Seog Ahn, Hyuncheol Oh, Jonas Baltrusaitis, James B Gloer, Donald T Wicklow.   

Abstract

Seven new compounds (aflaquinolones A-G; 1-7) containing dihydroquinolin-2-one and terpenoid units have been isolated from two different fungal sources. Two of these metabolites (1 and 2) were obtained from a Hawaiian fungicolous isolate of Aspergillus sp. (section Flavipedes; MYC-2048 = NRRL 58570), while the others were obtained from a marine Aspergillus isolate (SF-5044) collected in Korea. The structures of these compounds were determined mainly by analysis of NMR and MS data. Relative and absolute configurations were assigned on the basis of NOESY data and (1)H NMR J-values, comparison of calculated and experimental ECD spectra, and analysis of a Mosher's ester derivative of 2. Several known compounds, including alantrypinone, aspochalasins I and J, methyl 3,4,5-trimethoxy-2((2-((3-pyridinylcarbonyl)amino)benzoyl)amino)benzoate, and trans-dehydrocurvularin were also encountered in the extract of the Hawaiian isolate.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22295903      PMCID： PMC3311757          DOI： 10.1021/np200958r

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  18 in total

1.  Phylogenetic analysis of Aspergillus species using DNA sequences from four loci.

Authors:  Stephen W Peterson
Journal:  Mycologia       Date:  2008 Mar-Apr       Impact factor: 2.696

2.  Isolation, structure elucidation, and biomimetic total synthesis of versicolamide B, and the isolation of antipodal (-)-stephacidin A and (+)-notoamide B from Aspergillus versicolor NRRL 35600.

Authors:  Thomas J Greshock; Alan W Grubbs; Ping Jiao; Donald T Wicklow; James B Gloer; Robert M Williams
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

3.  Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.

Authors: 
Journal:  Phys Rev B Condens Matter       Date:  1988-01-15

4.  Density-functional approximation for the correlation energy of the inhomogeneous electron gas.

Authors: 
Journal:  Phys Rev B Condens Matter       Date:  1986-06-15

5.  Protuboxepins A and B and protubonines A and B from the marine-derived fungus Aspergillus sp. SF-5044.

Authors:  Sang Un Lee; Yukihiro Asami; Dongho Lee; Jae-Hyuk Jang; Jong Seog Ahn; Hyuncheol Oh
Journal:  J Nat Prod       Date:  2011-03-02       Impact factor: 4.050

6.  Synthesis and spectroscopic analysis of a stereoisomer library of the phytophthora mating hormone α1 and derived bis-Mosher esters.

Authors:  Reena Bajpai; Dennis P Curran
Journal:  J Am Chem Soc       Date:  2011-11-28       Impact factor: 15.419

7.  Botryolides A-E, decarestrictine analogues from a fungicolous Botryotrichum sp. (NRRL 38180).

Authors:  Arlene A Sy; Dale C Swenson; James B Gloer; Donald T Wicklow
Journal:  J Nat Prod       Date:  2007-12-30       Impact factor: 4.050

8.  Antifungal metabolites (monorden, monocillins I, II, III) from Colletotrichum graminicola, a systemic vascular pathogen of maize.

Authors:  Donald T Wicklow; Annalisa M Jordan; James B Gloer
Journal:  Mycol Res       Date:  2009-10-13

9.  UV-Guided isolation of alantrypinone, a novel Penicillium alkaloid.

Authors:  T O Larsen; K Frydenvang; J C Frisvad; C Christophersen
Journal:  J Nat Prod       Date:  1998-09       Impact factor: 4.050

10.  Calculation of solvent shifts on electronic g-tensors with the conductor-like screening model (COSMO) and its self-consistent generalization to real solvents (direct COSMO-RS).

Authors:  Sebastian Sinnecker; Arivazhagan Rajendran; Andreas Klamt; Michael Diedenhofen; Frank Neese
Journal:  J Phys Chem A       Date:  2006-02-16       Impact factor: 2.781
View more
  8 in total

1.  Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids.

Authors:  Yi Zou; Zhajun Zhan; Dehai Li; Mancheng Tang; Ralph A Cacho; Kenji Watanabe; Yi Tang
Journal:  J Am Chem Soc       Date:  2015-04-14       Impact factor: 15.419

2.  Potent Antifouling Marine Dihydroquinolin-2(1H)-one-Containing Alkaloids from the Gorgonian Coral-Derived Fungus Scopulariopsis sp.

Authors:  Chang-Lun Shao; Ru-Fang Xu; Chang-Yun Wang; Pei-Yuan Qian; Kai-Ling Wang; Mei-Yan Wei
Journal:  Mar Biotechnol (NY)       Date:  2015-04-02       Impact factor: 3.619

3.  Aspergillus section Nidulantes (formerly Emericella): Polyphasic taxonomy, chemistry and biology.

Authors:  A J Chen; J C Frisvad; B D Sun; J Varga; S Kocsubé; J Dijksterhuis; D H Kim; S-B Hong; J Houbraken; R A Samson
Journal:  Stud Mycol       Date:  2016-10-19       Impact factor: 16.097

4.  Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for Quinolones.

Authors:  Haoyu Tang; Yijie Tang; Igor V Kurnikov; Hsuan-Jen Liao; Nei-Li Chan; Maria G Kurnikova; Yisong Guo; Wei-Chen Chang
Journal:  ACS Catal       Date:  2021-06-06       Impact factor: 13.700

5.  Bioactive sulfur-containing sulochrin dimers and other metabolites from an Alternaria sp. isolate from a Hawaiian soil sample.

Authors:  Shengxin Cai; Jarrod B King; Lin Du; Douglas R Powell; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2014-09-29       Impact factor: 4.050

6.  Bioactive natural products from fungicolous Hawaiian isolates: secondary metabolites from a Phialemoniopsis sp.

Authors:  Amninder Kaur; Kristina D Rogers; Dale E Swenson; Patrick F Dowd; Donald T Wicklow; James B Gloer
Journal:  Mycology       Date:  2014-07-09

7.  Secondary metabolites from the Aspergillus sp. in the rhizosphere soil of Phoenix dactylifera (Palm tree).

Authors:  Raha Orfali; Shagufta Perveen
Journal:  BMC Chem       Date:  2019-08-07

8.  Innovative Three-Step Microwave-Promoted Synthesis of N-Propargyltetrahydroquinoline and 1,2,3-Triazole Derivatives as a Potential Factor Xa (FXa) Inhibitors: Drug Design, Synthesis, and Biological Evaluation.

Authors:  Fabián Santana-Romo; Carlos F Lagos; Yorley Duarte; Francisco Castillo; Yanina Moglie; Miguel A Maestro; Nitin Charbe; Flavia C Zacconi
Journal:  Molecules       Date:  2020-01-23       Impact factor: 4.411
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.