Literature DB >> 16179941

The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation.

A Golks1, D Brenner, I Schmitz, C Watzl, A Krueger, P H Krammer, I N Lavrik.   

Abstract

Formation of the CD95 (APO-1/Fas) death inducing signaling complex (DISC) plays a central role in CD95 signaling. Previously, CD95 DISC composition was analyzed by two-dimensional gel electrophoresis and four major cytotoxicity-associated proteins (CAP1-4) were found. CAP1 and CAP2 were defined to be unmodified and phosphorylated FADD, respectively. CAP4 was identified as procaspase-8a. CAP3, however, has remained elusive. In this study, we demonstrate that CAP3 is an intermediate of procaspase-8 processing. CAP3 is generated within seconds of DISC formation and subsequently processed to the prodomain of procaspase-8a that is known as p26 (CAP5). These findings lead to new insights into the mechanism of procaspase-8 processing and apoptosis initiation.

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Year:  2006        PMID： 16179941     DOI： 10.1038/sj.cdd.4401766

Source DB:  PubMed          Journal:  Cell Death Differ        ISSN： 1350-9047            Impact factor:   15.828


  15 in total

Review 1.  Regulation of CD95/Fas signaling at the DISC.

Authors:  I N Lavrik; P H Krammer
Journal:  Cell Death Differ       Date:  2011-11-11       Impact factor: 15.828

2.  Mechanism of caspase-2 activation upon DNA damage.

Authors:  V I Aksenova; G S Kopeina; A V Zamaraev; B D Zhivotovsky; I N Lavrik
Journal:  Dokl Biochem Biophys       Date:  2016-05-20       Impact factor: 0.788

3.  Dynamics within the CD95 death-inducing signaling complex decide life and death of cells.

Authors:  Leo Neumann; Carina Pforr; Joel Beaudouin; Alexander Pappa; Nicolai Fricker; Peter H Krammer; Inna N Lavrik; Roland Eils
Journal:  Mol Syst Biol       Date:  2010-03-09       Impact factor: 11.429

4.  Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation.

Authors:  Alexander Golks; Thi-Thanh Thao Tran; Jean Francois Goetschy; Danilo Guerini
Journal:  EMBO J       Date:  2007-09-20       Impact factor: 11.598

5.  CD95 stimulation results in the formation of a novel death effector domain protein-containing complex.

Authors:  Inna N Lavrik; Thomas Mock; Alexander Golks; Julia C Hoffmann; Simone Baumann; Peter H Krammer
Journal:  J Biol Chem       Date:  2008-07-17       Impact factor: 5.157

6.  Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis.

Authors:  J Beaudouin; C Liesche; S Aschenbrenner; M Hörner; R Eils
Journal:  Cell Death Differ       Date:  2013-01-11       Impact factor: 15.828

7.  A new C-terminal cleavage product of procaspase-8, p30, defines an alternative pathway of procaspase-8 activation.

Authors:  Julia C Hoffmann; Alexander Pappa; Peter H Krammer; Inna N Lavrik
Journal:  Mol Cell Biol       Date:  2009-06-15       Impact factor: 4.272

8.  Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain.

Authors:  K Schleich; J H Buchbinder; S Pietkiewicz; T Kähne; U Warnken; S Öztürk; M Schnölzer; M Naumann; P H Krammer; I N Lavrik
Journal:  Cell Death Differ       Date:  2015-10-23       Impact factor: 15.828

9.  Mathematical modeling of apoptosis.

Authors:  Kolja Schleich; Inna N Lavrik
Journal:  Cell Commun Signal       Date:  2013-06-26       Impact factor: 5.712

10.  Life and Death Decisions in the CD95 System: Main Pro-and Anti-Apoptotic Modulators.

Authors:  Inna N Lavrik; Peter H Krammer
Journal:  Acta Naturae       Date:  2009-04       Impact factor: 1.845
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