Literature DB >> 27193717

Mechanism of caspase-2 activation upon DNA damage.

V I Aksenova1, G S Kopeina2, A V Zamaraev1, B D Zhivotovsky1,3, I N Lavrik1,3.   

Abstract

The mechanism of caspase-2 activation in response to DNA damage was studied using human ovarian cancer cells Caov-4 treated with chemotherapeutic agent cisplatin. It was shown that mutations of the three cleavage sites of caspase-2 do not affect the assembly of the macromolecular complex of caspase-2 and its activation, but, conversely, stabilize this complex, most likely, via the inhibition of the dissociation of the active caspase-2.

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Year:  2016        PMID： 27193717     DOI： 10.1134/S1607672916020150

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  12 in total

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3.  In vitro reconstitution of the interactions in the PIDDosome.

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Review 5.  Caspase-2 function in response to DNA damage.

Authors:  Boris Zhivotovsky; Sten Orrenius
Journal:  Biochem Biophys Res Commun       Date:  2005-06-10       Impact factor: 3.575

6.  Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia.

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7.  Loss of caspase-2, -6 and -7 expression in gastric cancers.

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8.  The biochemical mechanism of caspase-2 activation.

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Journal:  Cell Death Differ       Date:  2004-11       Impact factor: 15.828

Review 9.  The enigma of caspase-2: the laymen's view.

Authors:  G Krumschnabel; B Sohm; F Bock; C Manzl; A Villunger
Journal:  Cell Death Differ       Date:  2008-11-21       Impact factor: 15.828

10.  The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme.

Authors:  J Yuan; S Shaham; S Ledoux; H M Ellis; H R Horvitz
Journal:  Cell       Date:  1993-11-19       Impact factor: 41.582
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  1 in total

1.  DNA damage-induced apoptosis and mitogen-activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells.

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Journal:  Environ Mol Mutagen       Date:  2018-02-05       Impact factor: 3.216
  1 in total

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