Literature DB >> 16178722

BX471: a CCR1 antagonist with anti-inflammatory activity in man.

Richard Horuk1.   

Abstract

Chemokines belong to a large family of chemoattractant molecules involved in the directed migration of immune cells. They achieve their cellular effects by direct interaction with cell surface receptors. The chemokine receptor CCR1 appears to be involved in a variety of proinflammatory and autoimmune diseases and this makes it a very attractive therapeutic target. This review discusses the identification, chemistry, biology and therapeutic potential of BX 471 a potent CCR1 antagonist that is currently in the clinic for a variety of indications.

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Year:  2005        PMID： 16178722     DOI： 10.2174/1389557054867057

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  10 in total

1.  Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice.

Authors:  Bärbel Lange-Sperandio; Agnes Trautmann; Oliver Eickelberg; Aparna Jayachandran; Stephan Oberle; Florian Schmidutz; Barbara Rodenbeck; Meike Hömme; Richard Horuk; Franz Schaefer
Journal:  Am J Pathol       Date:  2007-08-03       Impact factor: 4.307

2.  The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization.

Authors:  C Taylor Gilliland; Catherina L Salanga; Tetsuya Kawamura; JoAnn Trejo; Tracy M Handel
Journal:  J Biol Chem       Date:  2013-09-20       Impact factor: 5.157

Review 3.  Role of bone marrow-derived cells in colon cancer: lessons from mouse model studies.

Authors:  Makoto Mark Taketo
Journal:  J Gastroenterol       Date:  2009-02-13       Impact factor: 7.527

4.  Integrated network analysis of transcriptomic and proteomic data in psoriasis.

Authors:  Eleonora Piruzian; Sergey Bruskin; Alex Ishkin; Rustam Abdeev; Sergey Moshkovskii; Stanislav Melnik; Yuri Nikolsky; Tatiana Nikolskaya
Journal:  BMC Syst Biol       Date:  2010-04-08

5.  Identifying bias in CCR1 antagonists using radiolabelled binding, receptor internalization, β-arrestin translocation and chemotaxis assays.

Authors:  A Gilchrist; T D Gauntner; A Fazzini; K M Alley; D S Pyen; J Ahn; S J Ha; A Willett; S E Sansom; J L Yarfi; K A Bachovchin; M R Mazzoni; J R Merritt
Journal:  Br J Pharmacol       Date:  2014-11       Impact factor: 8.739

6.  Expression, purification and in vitro functional reconstitution of the chemokine receptor CCR1.

Authors:  Samantha J Allen; Sofia Ribeiro; Richard Horuk; Tracy M Handel
Journal:  Protein Expr Purif       Date:  2009-03-09       Impact factor: 1.650

7.  Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor.

Authors:  Antal Rot; Clive McKimmie; Claire L Burt; Kenneth J Pallas; Thomas Jamieson; Monika Pruenster; Richard Horuk; Robert J B Nibbs; Gerard J Graham
Journal:  J Immunol       Date:  2013-05-13       Impact factor: 5.422

8.  Antibodies to MHC class I induce autoimmunity: role in the pathogenesis of chronic rejection.

Authors:  Naohiko Fukami; Sabarinathan Ramachandran; Deepti Saini; Michael Walter; William Chapman; G Alexander Patterson; Thalachallour Mohanakumar
Journal:  J Immunol       Date:  2009-01-01       Impact factor: 5.422

9.  CCR1 knockdown suppresses human non-small cell lung cancer cell invasion.

Authors:  Chang-Li Wang; Bing-Sheng Sun; Yong Tang; Hong-Qing Zhuang; Wei-Zhi Cao
Journal:  J Cancer Res Clin Oncol       Date:  2008-10-30       Impact factor: 4.553

10.  Effects of blocking chemokine receptor CCR1 with BX471 in two models of fibrosis prevention and rescue in mice.

Authors:  Susanne N Weber; Irina Nowak; Frank Grünhage; Frank Lammert
Journal:  Biochem Biophys Rep       Date:  2021-07-15
  10 in total

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