Literature DB >> 16178535

Heterobifunctional multivalent inhibitor-adaptor mediates specific aggregation between Shiga toxin and a pentraxin.

Dmitry Solomon1, Pavel I Kitov, Eugenia Paszkiewicz, Gordon A Grant, Joanna M Sadowska, David R Bundle.   

Abstract

[reaction: see text] The first example of a multivalent heterofunctional inhibitor-adaptor, called "BAIT", is described. This multivalent inhibitor-adaptor is able to capture a "target" receptor (Shiga toxin) through its recognition of one ligand of a heterobivalent headgroup while the other ligand binds to an endogenous "trap" protein (serum amyloid P component, SAP). BAIT showed markedly enhanced inhibition of toxin activity. An efficient synthesis of this multivalent cluster containing heterobifunctional ligands was accomplished by chemical and chemoenzymatic approaches.

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Year:  2005        PMID： 16178535     DOI： 10.1021/ol051529+

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  12 in total

1.  Unexpected enhancement in biological activity of a GPCR ligand induced by an oligoethylene glycol substituent.

Authors:  Chutima Jiarpinitnun; Laura L Kiessling
Journal:  J Am Chem Soc       Date:  2010-07-07       Impact factor: 15.419

2.  In vivo supramolecular templating enhances the activity of multivalent ligands: a potential therapeutic against the Escherichia coli O157 AB5 toxins.

Authors:  Pavel I Kitov; George L Mulvey; Thomas P Griener; Tomasz Lipinski; Dmitry Solomon; Eugenia Paszkiewicz; Jared M Jacobson; Joanna M Sadowska; Missao Suzuki; Ken-Ichi Yamamura; Glen D Armstrong; David R Bundle
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-27       Impact factor: 11.205

Review 3.  Multivalent Inhibitors of Channel-Forming Bacterial Toxins.

Authors:  Goli Yamini; Ekaterina M Nestorovich
Journal:  Curr Top Microbiol Immunol       Date:  2017       Impact factor: 4.291

4.  A synthetic trivalent hapten that aggregates anti-2,4-DNP IgG into bicyclic trimers.

Authors:  Basar Bilgiçer; Demetri T Moustakas; George M Whitesides
Journal:  J Am Chem Soc       Date:  2007-02-28       Impact factor: 15.419

5.  Supramolecular complexing of membane Siglec CD22 mediated by a polyvalent heterobifunctional ligand that templates on IgM.

Authors:  Lina Cui; Pavel I Kitov; Gladys C Completo; James C Paulson; David R Bundle
Journal:  Bioconjug Chem       Date:  2011-03-23       Impact factor: 4.774

6.  Architecture Effects on the Binding of Cholera Toxin by Helical Glycopolypeptides.

Authors:  Shuang Liu; Kristi L Kiick
Journal:  Macromolecules       Date:  2008-02-12       Impact factor: 5.985

7.  Bifunctional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells.

Authors:  Mary K O'Reilly; Brian E Collins; Shoufa Han; Liang Liao; Cory Rillahan; Pavel I Kitov; David R Bundle; James C Paulson
Journal:  J Am Chem Soc       Date:  2008-05-28       Impact factor: 15.419

Review 8.  Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.

Authors:  Timothy W Corson; Nicholas Aberle; Craig M Crews
Journal:  ACS Chem Biol       Date:  2008-11-21       Impact factor: 5.100

9.  The crystal structure of shiga toxin type 2 with bound disaccharide guides the design of a heterobifunctional toxin inhibitor.

Authors:  Jared M Jacobson; Jiang Yin; Pavel I Kitov; George Mulvey; Tom P Griener; Michael N G James; Glen Armstrong; David R Bundle
Journal:  J Biol Chem       Date:  2013-11-13       Impact factor: 5.157

10.  Impact of the nature and size of the polymeric backbone on the ability of heterobifunctional ligands to mediate shiga toxin and serum amyloid p component ternary complex formation.

Authors:  Pavel I Kitov; Eugenia Paszkiewicz; Joanna M Sadowska; Zhicheng Deng; Marya Ahmed; Ravin Narain; Thomas P Griener; George L Mulvey; Glen D Armstrong; David R Bundle
Journal:  Toxins (Basel)       Date:  2011-08-25       Impact factor: 4.546
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