Literature DB >> 20536128

Unexpected enhancement in biological activity of a GPCR ligand induced by an oligoethylene glycol substituent.

Chutima Jiarpinitnun1, Laura L Kiessling.   

Abstract

Polyethylene glycol (PEG) is widely used, and many biologically active molecules are modified with oligoethylene glycol substituents to enhance their half-lives in circulation. The pervasive use of PEG substituents is partly due to their presumed inertness. Our investigation of formyl peptide receptor (FPR)-mediated chemotaxis reveals that oligoethylene glycol substitution can enhance the ability of the peptide chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLF) to activate signal transduction through FPR, a transmembrane G-protein-coupled receptor.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20536128      PMCID： PMC2913153          DOI： 10.1021/ja102640c

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  27 in total

1.  Sensitive determination of cell number using the CyQUANT cell proliferation assay.

Authors:  L J Jones; M Gray; S T Yue; R P Haugland; V L Singer
Journal:  J Immunol Methods       Date:  2001-08-01       Impact factor: 2.303

Review 2.  Effect of pegylation on pharmaceuticals.

Authors:  J Milton Harris; Robert B Chess
Journal:  Nat Rev Drug Discov       Date:  2003-03       Impact factor: 84.694

3.  Fluorescence analysis of the size of a binding pocket of a peptide receptor at natural abundance.

Authors:  L A Sklar; S P Fay; B E Seligmann; R J Freer; N Muthukumaraswamy; H Mueller
Journal:  Biochemistry       Date:  1990-01-16       Impact factor: 3.162

4.  Self-assembled organic monolayers: model systems for studying adsorption of proteins at surfaces.

Authors:  K L Prime; G M Whitesides
Journal:  Science       Date:  1991-05-24       Impact factor: 47.728

5.  Undifferentiated U937 cells transfected with chemoattractant receptors: a model system to investigate chemotactic mechanisms and receptor structure/function relationships.

Authors:  R R Kew; T Peng; S J DiMartino; D Madhavan; S J Weinman; D Cheng; E R Prossnitz
Journal:  J Leukoc Biol       Date:  1997-03       Impact factor: 4.962

Review 6.  The molecular biology of leukocyte chemoattractant receptors.

Authors:  P M Murphy
Journal:  Annu Rev Immunol       Date:  1994       Impact factor: 28.527

7.  Ligand-dependent inhibition of oligomerization at the human thyrotropin receptor.

Authors:  Rauf Latif; Peter Graves; Terry F Davies
Journal:  J Biol Chem       Date:  2002-09-09       Impact factor: 5.157

8.  Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice.

Authors:  T Yamaoka; Y Tabata; Y Ikada
Journal:  J Pharm Sci       Date:  1994-04       Impact factor: 3.534

Review 9.  Chemistry for peptide and protein PEGylation.

Authors:  M J Roberts; M D Bentley; J M Harris
Journal:  Adv Drug Deliv Rev       Date:  2002-06-17       Impact factor: 15.470

10.  Dimeric chemotactic peptides discriminate between chemotaxis and superoxide production of human neutrophils.

Authors:  M Miyazaki; H Kodama; I Fujita; Y Hamasaki; S Miyazaki; M Kondo
Journal:  J Biochem       Date:  1995-03       Impact factor: 3.387
View more
  5 in total

1.  Design, synthesis and biological evaluation of bivalent ligands against A(1)-D(1) receptor heteromers.

Authors:  Jian Shen; Lei Zhang; Wan-ling Song; Tao Meng; Xin Wang; Lin Chen; Lin-yin Feng; Ye-chun Xu; Jing-kang Shen
Journal:  Acta Pharmacol Sin       Date:  2013-01-21       Impact factor: 6.150

2.  γ-AApeptides: Design, Structure, and Applications.

Authors:  Yan Shi; Peng Teng; Peng Sang; Fengyu She; Lulu Wei; Jianfeng Cai
Journal:  Acc Chem Res       Date:  2016-02-22       Impact factor: 22.384

3.  Protein Mimetic and Anticancer Properties of Monocyte-Targeting Peptide Amphiphile Micelles.

Authors:  Christopher Poon; Sampreeti Chowdhuri; Cheng-Hsiang Kuo; Yun Fang; Francis J Alenghat; Danielle Hyatt; Kian Kani; Mitchell E Gross; Eun Ji Chung
Journal:  ACS Biomater Sci Eng       Date:  2017-09-28

Review 4.  Understanding the Role and Impact of Poly (Ethylene Glycol) (PEG) on Nanoparticle Formulation: Implications for COVID-19 Vaccines.

Authors:  Esperanza Padín-González; Pearl Lancaster; Massimo Bottini; Paolo Gasco; Lang Tran; Bengt Fadeel; Terence Wilkins; Marco P Monopoli
Journal:  Front Bioeng Biotechnol       Date:  2022-06-07

5.  Design, synthesis and characterization of fMLF-mimicking AApeptides.

Authors:  Yaogang Hu; Ni Cheng; Haifan Wu; Samuel Kang; Richard D Ye; Jianfeng Cai
Journal:  Chembiochem       Date:  2014-09-15       Impact factor: 3.164
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.