Literature DB >> 1617834

A YIGSR-containing novel mutein without the detrimental effect of human TNF-alpha of enhancing experimental pulmonary metastasis.

K Miyata1, M Kato, H Shikama, K Nishimura, N Sakae, K Kawagoe, T Nishikawa, K Kuroda, K Yamaguchi, Y Aoyama.   

Abstract

The injection of B16F10 melanoma cells with recombinant human tumor necrosis factor alpha (TNF-alpha) into the tail vein of C57BL/6 mice resulted in 2- to 25-fold more metastatic foci in the lungs than the injection of tumor cells alone. Clearly, TNF-alpha significantly enhanced experimental tumor metastasis. Furthermore, it enhanced the metastasis of Lewis lung carcinoma cells. In contrast, a mutein of TNF-alpha, designated as F4236, having the cell-adhesive sequence (Tyr-Ile-Gly-Ser-Arg) at the N-terminus of the TNF molecule did not enhance metastasis, but rather exhibited similar antitumor activity to wild-type TNF-alpha in fibrosarcoma-bearing mice.

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Year:  1992        PMID： 1617834     DOI： 10.1007/bf00133562

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN： 0262-0898            Impact factor:   5.150


  23 in total

Review 1.  Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions.

Authors:  J Vilcek; T H Lee
Journal:  J Biol Chem       Date:  1991-04-25       Impact factor: 5.157

2.  Intralesional tumour necrosis factor combined with interferon gamma in metastatic melanoma.

Authors:  S Retsas; M Leslie; D Bottomley
Journal:  BMJ       Date:  1989-05-13

3.  Protective activity of recombinant murine tumor necrosis factor-alpha and interferon-gamma against experimental murine lung carcinoma metastases.

Authors:  R M Schultz; M G Altom
Journal:  J Interferon Res       Date:  1990-04

4.  Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding.

Authors:  J Graf; Y Iwamoto; M Sasaki; G R Martin; H K Kleinman; F A Robey; Y Yamada
Journal:  Cell       Date:  1987-03-27       Impact factor: 41.582

5.  Rapid and efficient site-specific mutagenesis without phenotypic selection.

Authors:  T A Kunkel; J D Roberts; R A Zakour
Journal:  Methods Enzymol       Date:  1987       Impact factor: 1.600

6.  YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation.

Authors:  Y Iwamoto; F A Robey; J Graf; M Sasaki; H K Kleinman; Y Yamada; G R Martin
Journal:  Science       Date:  1987-11-20       Impact factor: 47.728

7.  An inducible endothelial cell surface glycoprotein mediates melanoma adhesion.

Authors:  G E Rice; M P Bevilacqua
Journal:  Science       Date:  1989-12-08       Impact factor: 47.728

Review 8.  Tumour necrosis factor: a cytokine with multiple biological activities.

Authors:  G Semenzato
Journal:  Br J Cancer       Date:  1990-03       Impact factor: 7.640

9.  Suppression of experimental lung colonization of a metastatic variant of murine colon adenocarcinoma 26 by a monoclonal antibody 8F11 inhibiting tumor cell-induced platelet aggregation.

Authors:  Y Sugimoto; M Watanabe; T Oh-hara; S Sato; T Isoe; T Tsuruo
Journal:  Cancer Res       Date:  1991-02-01       Impact factor: 12.701

10.  Preventive and antiproliferative effects of tumor necrosis factor against experimental hepatic metastases of mouse colon-26 tumor.

Authors:  Y Nishiyama; S Fuchimoto; K Orita
Journal:  Jpn J Cancer Res       Date:  1989-04
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  5 in total

1.  Expression of matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) induced by tumour necrosis factor alpha correlates with metastatic ability in a human osteosarcoma cell line.

Authors:  A Kawashima; I Nakanishi; H Tsuchiya; A Roessner; K Obata; Y Okada
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

2.  Human lymphotoxin mutein lacks hypotensive activity but has higher in vivo antitumor activity than lymphotoxin or tumor necrosis factor.

Authors:  M Taniyama; T Morita; Y Yamagishi; A Kato; C Bando; N Okawa; A Kaji
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

3.  A novel Mutein of TNFalpha Containing the Arg-Gly-Asp Sequence Shows Reduced Toxicity in Intestine.

Authors:  H Shikama; K Miyata; N Sakae; K Kuroda; K Nishimura; S Yotsuya; M Kato
Journal:  Mediators Inflamm       Date:  1994       Impact factor: 4.711

4.  Preferential activity of wild-type and mutant tumor necrosis factor-alpha against tumor-derived endothelial-like cells.

Authors:  K Kuroda; K Miyata; Y Tsutsumi; S Tsunoda; K Nishimura; Y Mitsuishi; S Nakagawa; T Mayumi
Journal:  Jpn J Cancer Res       Date:  2000-01

5.  Enhancement of experimental metastasis by tumor necrosis factor.

Authors:  P Orosz; B Echtenacher; W Falk; J Rüschoff; D Weber; D N Männel
Journal:  J Exp Med       Date:  1993-05-01       Impact factor: 14.307
  5 in total

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