Literature DB >> 16177389

Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model.

Krzysztof Trzcinski1, Claudette Thompson, Richard Malley, Marc Lipsitch.   

Abstract

In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4(+) T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.

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Year:  2005        PMID： 16177389      PMCID： PMC1230924          DOI： 10.1128/IAI.73.10.7043-7046.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

1.  Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae.

Authors:  D E Briles; E Ades; J C Paton; J S Sampson; G M Carlone; R C Huebner; A Virolainen; E Swiatlo; S K Hollingshead
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

2.  CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization.

Authors:  Richard Malley; Krzysztof Trzcinski; Amit Srivastava; Claudette M Thompson; Porter W Anderson; Marc Lipsitch
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-21       Impact factor: 11.205

3.  Serum serotype-specific pneumococcal anticapsular immunoglobulin g concentrations after immunization with a 9-valent conjugate pneumococcal vaccine correlate with nasopharyngeal acquisition of pneumococcus.

Authors:  Ron Dagan; Noga Givon-Lavi; Drora Fraser; Marc Lipsitch; George R Siber; Robert Kohberger
Journal:  J Infect Dis       Date:  2005-06-28       Impact factor: 5.226

4.  Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis media.

Authors:  S Rapola; V Jäntti; R Haikala; R Syrjänen; G M Carlone; J S Sampson; D E Briles; J C Paton; A K Takala; T M Kilpi; H Käyhty
Journal:  J Infect Dis       Date:  2000-09-05       Impact factor: 5.226

5.  Competition among Streptococcus pneumoniae for intranasal colonization in a mouse model.

Authors:  M Lipsitch; J K Dykes; S E Johnson; E W Ades; J King; D E Briles; G M Carlone
Journal:  Vaccine       Date:  2000-06-15       Impact factor: 3.641

6.  Immunogenicity and impact on nasopharyngeal carriage of a nonavalent pneumococcal conjugate vaccine.

Authors:  N Mbelle; R E Huebner; A D Wasas; A Kimura; I Chang; K P Klugman
Journal:  J Infect Dis       Date:  1999-10       Impact factor: 5.226

7.  Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae.

Authors:  A D Ogunniyi; R L Folland; D E Briles; S K Hollingshead; J C Paton
Journal:  Infect Immun       Date:  2000-05       Impact factor: 3.441

8.  Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization.

Authors:  Tera L McCool; Jeffrey N Weiser
Journal:  Infect Immun       Date:  2004-10       Impact factor: 3.441

9.  A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene.

Authors:  D Kitamura; J Roes; R Kühn; K Rajewsky
Journal:  Nature       Date:  1991-04-04       Impact factor: 49.962

10.  Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease?

Authors:  Marc Lipsitch; Cynthia G Whitney; Elizabeth Zell; Tarja Kaijalainen; Ron Dagan; Richard Malley
Journal:  PLoS Med       Date:  2005-01-25       Impact factor: 11.069
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  32 in total

1.  Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine.

Authors:  Birgit Simell; Anu Nurkka; Mika Lahdenkari; Noga Givon-Lavi; Helena Käyhty; Ron Dagan; Jukka Jokinen
Journal:  Clin Vaccine Immunol       Date:  2011-11-09

2.  Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin.

Authors:  Shaper Mirza; Landon Wilson; William H Benjamin; Jan Novak; Stephen Barnes; Susan K Hollingshead; David E Briles
Journal:  Infect Immun       Date:  2011-03-21       Impact factor: 3.441

3.  Age- and serogroup-related differences in observed durations of nasopharyngeal carriage of penicillin-resistant pneumococci.

Authors:  Liselotte Högberg; Patricia Geli; Håkan Ringberg; Eva Melander; Marc Lipsitch; Karl Ekdahl
Journal:  J Clin Microbiol       Date:  2007-01-03       Impact factor: 5.948

Review 4.  Patterns of antigenic diversity and the mechanisms that maintain them.

Authors:  Marc Lipsitch; Justin J O'Hagan
Journal:  J R Soc Interface       Date:  2007-10-22       Impact factor: 4.118

5.  Mechanisms in the serotype-independent pneumococcal immunity induced in mice by intranasal vaccination with the cell wall polysaccharide.

Authors:  Ying-Jie Lu; Ian Chr Skovsted; Claudette M Thompson; Porter W Anderson; Richard Malley
Journal:  Microb Pathog       Date:  2009-07-03       Impact factor: 3.738

6.  Association of Pneumococcal Protein Antigen Serology With Age and Antigenic Profile of Colonizing Isolates.

Authors:  Taj Azarian; Lindsay R Grant; Maria Georgieva; Laura L Hammitt; Raymond Reid; Stephen D Bentley; David Goldblatt; Mathuran Santosham; Robert Weatherholtz; Paula Burbidge; Novalene Goklish; Claudette M Thompson; William P Hanage; Kate L O'Brien; Marc Lipsitch
Journal:  J Infect Dis       Date:  2017-03-01       Impact factor: 5.226

7.  Mucosal immunization with the live attenuated vaccine SPY1 induces humoral and Th2-Th17-regulatory T cell cellular immunity and protects against pneumococcal infection.

Authors:  Xiuyu Xu; Hong Wang; Yusi Liu; Yiping Wang; Lingbing Zeng; Kaifeng Wu; Jianmin Wang; Feng Ma; Wenchun Xu; Yibing Yin; Xuemei Zhang
Journal:  Infect Immun       Date:  2014-10-13       Impact factor: 3.441

8.  Defective pneumococcal-specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization.

Authors:  Sarah J Glennie; Dominic Banda; Kate Gould; Jason Hinds; Arox Kamngona; Dean D B Everett; Neil A Williams; Robert S Heyderman
Journal:  Clin Infect Dis       Date:  2012-09-28       Impact factor: 9.079

Review 9.  Mouse models for the study of mucosal vaccination against otitis media.

Authors:  Albert Sabirov; Dennis W Metzger
Journal:  Vaccine       Date:  2008-02-04       Impact factor: 3.641

10.  Antibodies to pneumococcal proteins PhtD, CbpA, and LytC in Filipino pregnant women and their infants in relation to pneumococcal carriage.

Authors:  Emma Holmlund; Beatriz Quiambao; Jukka Ollgren; Teija Jaakkola; Cécile Neyt; Jan Poolman; Hanna Nohynek; Helena Käyhty
Journal:  Clin Vaccine Immunol       Date:  2009-04-29
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