Literature DB >> 22072724

Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine.

Birgit Simell1, Anu Nurkka, Mika Lahdenkari, Noga Givon-Lavi, Helena Käyhty, Ron Dagan, Jukka Jokinen.   

Abstract

Association of pneumococcal nasopharyngeal carriage with the concentration and opsonophagocytic activity (OPA) of serum serotype-specific antibodies was determined for toddlers 1 month after immunization with a 9-valent pneumococcal conjugate vaccine. Higher anti-serotype 14 and anti-serotype 19F IgG and anti-serotype 14 IgM correlated with a lowered probability of pneumococcal acquisition. Postvaccination OPA did not correlate with pneumococcal carriage.

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Year:  2011        PMID： 22072724      PMCID： PMC3255944          DOI： 10.1128/CVI.05369-11

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


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