Literature DB >> 16177070

Virus-induced inhibition of CD1d1-mediated antigen presentation: reciprocal regulation by p38 and ERK.

Gourapura J Renukaradhya1, Tonya J Roberts Webb, Masood A Khan, Yin Ling Lin, Wenjun Du, Jacquelyn Gervay-Hague, Randy R Brutkiewicz.   

Abstract

A critical component of the host's innate immune response involves lipid Ag presentation by CD1d molecules to NK T cells. In this study we used murine CD1d1-transfected L (L-CD1) cells to study the effect of viruses on CD1d-mediated Ag presentation to NKT cells and found that an infection with vesicular stomatitis and vaccinia (but not lymphocytic choriomeningitis) virus inhibited murine CD1d1-mediated Ag presentation. This was under the reciprocal control of the MAPKs, p38 and ERK, and was due to changes in the intracellular trafficking of CD1d1. The reciprocal regulation of CD1d1-mediated Ag presentation by MAPK suggests that the targeting of these pathways is a novel means of immune evasion by viruses.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16177070     DOI： 10.4049/jimmunol.175.7.4301

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  33 in total

Review 1.  Turned on by danger: activation of CD1d-restricted invariant natural killer T cells.

Authors:  Victoria Lawson
Journal:  Immunology       Date:  2012-09       Impact factor: 7.397

Review 2.  Lipid antigens in immunity.

Authors:  C Marie Dowds; Sabin-Christin Kornell; Richard S Blumberg; Sebastian Zeissig
Journal:  Biol Chem       Date:  2014-01       Impact factor: 3.915

Review 3.  Immune evasion of the CD1d/NKT cell axis.

Authors:  Randy R Brutkiewicz; Laura Yunes-Medina; Jianyun Liu
Journal:  Curr Opin Immunol       Date:  2018-05-04       Impact factor: 7.486

Review 4.  Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity.

Authors:  Amelia R Hofstetter; Lucy C Sullivan; Aron E Lukacher; Andrew G Brooks
Journal:  Curr Opin Immunol       Date:  2010-10-21       Impact factor: 7.486

5.  Apoptosis-induced inhibition of CD1d-mediated antigen presentation: different roles for caspases and signal transduction pathways.

Authors:  Masood A Khan; Venkataraman Sriram; Gourapura J Renukaradhya; Wenjun Du; Jacquelyn Gervay-Hague; Randy R Brutkiewicz
Journal:  Immunology       Date:  2008-03-14       Impact factor: 7.397

6.  Macrophage p38 mitogen-activated protein kinase activity regulates invariant natural killer T-cell responses during Borrelia burgdorferi infection.

Authors:  Kelly Hawley; Nicolás Navasa; Chris M Olson; Tonya C Bates; Renu Garg; Michael N Hedrick; Dietrich Conze; Mercedes Rincón; Juan Anguita
Journal:  J Infect Dis       Date:  2012-05-02       Impact factor: 5.226

7.  Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.

Authors:  Crystal C Walline; Sarah N Deffit; Nan Wang; Lynette M Guindon; Victoria L Crotzer; Jianyun Liu; Kristin Hollister; Laurence C Eisenlohr; Randy R Brutkiewicz; Mark H Kaplan; Janice S Blum
Journal:  Immunology       Date:  2014-04       Impact factor: 7.397

8.  Vesicular stomatitis virus matrix protein impairs CD1d-mediated antigen presentation through activation of the p38 MAPK pathway.

Authors:  Gourapura J Renukaradhya; Masood A Khan; Daniel Shaji; Randy R Brutkiewicz
Journal:  J Virol       Date:  2008-09-24       Impact factor: 5.103

9.  A Thr/Ser dual residue motif in the cytoplasmic tail of human CD1d is important for the down-regulation of antigen presentation following a herpes simplex virus 1 infection.

Authors:  Jianyun Liu; Nicole L Glosson; Wenjun Du; Jacquelyn Gervay-Hague; Randy R Brutkiewicz
Journal:  Immunology       Date:  2013-10       Impact factor: 7.397

10.  Specific NFkappaB subunit activation and kinetics of cytokine induction in adenoviral keratitis.

Authors:  Jaya Rajaiya; Neda Sadeghi; James Chodosh
Journal:  Mol Vis       Date:  2009-12-25       Impact factor: 2.367
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.