Literature DB >> 1617652

An altered 11-kilobase transcript in leukemic cell lines with the t(4;11)(q21;q23) chromosome translocation.

G Cimino1, T Nakamura, Y Gu, O Canaani, R Prasad, W M Crist, A J Carroll, M Baer, C D Bloomfield, P C Nowell.   

Abstract

The 11q23 chromosome band is frequently associated with chromosomal aberrations in human leukemias. We have previously cloned a DNA fragment derived from chromosome 11 which could be used as a probe to detect rearrangements in DNAs from the leukemic cells of patients with the t(4;11), t(9;11), and t(11;19) translocations. In this study we now show that the same probe detects DNA rearrangements in malignant cells from patients with the t(1;11), t(6;11), t(10;11), and del (11q23) chromosomal abnormalities. A second probe obtained from a region located centrometric to the breakpoint cluster detects major and minor transcripts of 12.5 and 11.5 kilobases, respectively, in all cell lines examined. The same probe identifies an altered 11-kilobase RNA in all three independent cell lines with the t(4;11)(q21;q23) chromosome translocation.

Entities:  

Mesh：

Year:  1992        PMID： 1617652

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  12 in total

1.  Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.

Authors:  P H Domer; S S Fakharzadeh; C S Chen; J Jockel; L Johansen; G A Silverman; J H Kersey; S J Korsmeyer
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-15       Impact factor: 11.205

2.  Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia.

Authors:  P J Kourlas; M P Strout; B Becknell; M L Veronese; C M Croce; K S Theil; R Krahe; T Ruutu; S Knuutila; C D Bloomfield; M A Caligiuri
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

3.  Detection of chromosome 11q23 involving translocations by pulsed field gel electrophoresis.

Authors:  J Finke; R Kunzmann; W Lange
Journal:  Ann Hematol       Date:  1994-03       Impact factor: 3.673

4.  Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

Authors:  T Nakamura; H Alder; Y Gu; R Prasad; O Canaani; N Kamada; R P Gale; B Lange; W M Crist; P C Nowell
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-15       Impact factor: 11.205

5.  Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

Authors:  Q Ma; H Alder; K K Nelson; D Chatterjee; Y Gu; T Nakamura; E Canaani; C M Croce; L D Siracusa; A M Buchberg
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

6.  Cloning of cDNAs of the MLL gene that detect DNA rearrangements and altered RNA transcripts in human leukemic cells with 11q23 translocations.

Authors:  N R McCabe; R C Burnett; H J Gill; M J Thirman; D Mbangkollo; M Kipiniak; E van Melle; S Ziemin-van der Poel; J D Rowley; M O Diaz
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

7.  The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase.

Authors:  Y Gu; G Cimino; H Alder; T Nakamura; R Prasad; O Canaani; D T Moir; C Jones; P C Nowell; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

8.  Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.

Authors:  P H Sorensen; C S Chen; F O Smith; D C Arthur; P H Domer; I D Bernstein; S J Korsmeyer; G D Hammond; J H Kersey
Journal:  J Clin Invest       Date:  1994-01       Impact factor: 14.808

9.  ALL-1 partial duplication in acute leukemia.

Authors:  S A Schichman; M A Caligiuri; Y Gu; M P Strout; E Canaani; C D Bloomfield; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

10.  Chromosomal localization of the human histone H2A.X gene to 11q23.2-q23.3 by fluorescence in situ hybridization.

Authors:  V S Ivanova; D Zimonjic; N Popescu; W M Bonner
Journal:  Hum Genet       Date:  1994-09       Impact factor: 4.132
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