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Literature DB >> 16174894

Intracerebral hemorrhage: pathophysiology and therapy.

Guohua Xi¹, Matthew E Fewel, Ya Hua, B Gregory Thompson, Julian T Hoff, Richard F Keep.

Abstract

Spontaneous intracerebral hemorrhage, from several sources, causes instantaneous mass effect, disruption of surrounding brain, and often an early neurological death. If the patient survives the initial event, the hematoma can lead to secondary brain injury, neurological deficits, and, occasionally, delayed fatality. The mechanisms that trigger pathophysiological changes in and around the hematoma are becoming better understood, offering new therapeutic opportunities.

Entities: Disease Species

Mesh：

Substances：
Hemoglobins

Year: 2004 PMID： 16174894 DOI： 10.1385/ncc:1:1:5

Source DB: PubMed Journal: Neurocrit Care ISSN： 1541-6933 Impact factor: 3.210

94 in total

1. MASSIVE CEREBRAL HEMORRHAGE. CLINICAL AND PATHOLOGICAL CORRELATIONS.

Authors: N MUTLU; R G BERRY; B J ALPERS
Journal: Arch Neurol Date: 1963-06

2. Early metabolic alterations in edematous perihematomal brain regions following experimental intracerebral hemorrhage.

Authors: K R Wagner; G Xi; Y Hua; M Kleinholz; G M de Courten-Myers; R E Myers
Journal: J Neurosurg Date: 1998-06 Impact factor: 5.115

3. Nuclear factor-kappaB and cell death after experimental intracerebral hemorrhage in rats.

Authors: S L Hickenbottom; J C Grotta; R Strong; L A Denner; J Aronowski
Journal: Stroke Date: 1999-11 Impact factor: 7.914

4. Comparison of cerebral blood flow and injury following intracerebral and subdural hematoma in the rat.

Authors: T R Patel; G P Schielke; J T Hoff; R F Keep; A Lorris Betz
Journal: Brain Res Date: 1999-05-22 Impact factor: 3.252

5. Protective effects of free radical inhibitors in intracerebral hemorrhage in rat.

Authors: J Peeling; H J Yan; S G Chen; M Campbell; M R Del Bigio
Journal: Brain Res Date: 1998-06-08 Impact factor: 3.252

6. Effects of experimental intracerebral hemorrhage on blood flow, capillary permeability, and histochemistry.

Authors: F P Nath; P T Kelly; A Jenkins; A D Mendelow; D I Graham; G M Teasdale
Journal: J Neurosurg Date: 1987-04 Impact factor: 5.115

7. Chronological changes in brain edema induced by experimental intracerebral hematoma in cats.

Authors: H Tomita; U Ito; K Ohno; K Hirakawa
Journal: Acta Neurochir Suppl (Wien) Date: 1994

8. Local fibrinolysis and aspiration of intracerebral hematomas in rats. An experimental study using MR monitoring.

Authors: W Deinsberger; M Hartmann; J Vogel; O Jansen; W Kuschinsky; K Sartor; D K Böker
Journal: Neurol Res Date: 1998-06 Impact factor: 2.448

Review 9. Ultra-early hemostatic therapy for intracerebral hemorrhage.

Authors: Stephan A Mayer
Journal: Stroke Date: 2003-01 Impact factor: 7.914

10. Edema from intracerebral hemorrhage: the role of thrombin.

Authors: K R Lee; G P Colon; A L Betz; R F Keep; S Kim; J T Hoff
Journal: J Neurosurg Date: 1996-01 Impact factor: 5.115

20 in total

1. Decompressive craniectomy with clot evacuation in large hemispheric hypertensive intracerebral hemorrhage.

Authors: J M K Murthy; G V S Chowdary; T V R K Murthy; P Syed Ameer Bhasha; T Jaishree Naryanan
Journal: Neurocrit Care Date: 2005 Impact factor: 3.210

2. [Recommendations of the European Stroke Initiative for the diagnosis and treatment of spontaneous intracerebral haemorrhage].

Authors: S Külkens; P Ringleb; J Diedler; W Hacke; T Steiner
Journal: Nervenarzt Date: 2006-08 Impact factor: 1.214

3. The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change.

Authors: Joo Eun Jung; Guanghua Sun; Jesus Bautista Garrido; Lidiya Obertas; Alexis S Mobley; Shun-Ming Ting; Xiurong Zhao; Jaroslaw Aronowski
Journal: J Neurosci Date: 2020-01-24 Impact factor: 6.167

Intracerebral hemorrhage: pathophysiology and therapy.

1. MASSIVE CEREBRAL HEMORRHAGE. CLINICAL AND PATHOLOGICAL CORRELATIONS.

2. Early metabolic alterations in edematous perihematomal brain regions following experimental intracerebral hemorrhage.

3. Nuclear factor-kappaB and cell death after experimental intracerebral hemorrhage in rats.

4. Comparison of cerebral blood flow and injury following intracerebral and subdural hematoma in the rat.

5. Protective effects of free radical inhibitors in intracerebral hemorrhage in rat.

6. Effects of experimental intracerebral hemorrhage on blood flow, capillary permeability, and histochemistry.

7. Chronological changes in brain edema induced by experimental intracerebral hematoma in cats.

8. Local fibrinolysis and aspiration of intracerebral hematomas in rats. An experimental study using MR monitoring.

Review 9. Ultra-early hemostatic therapy for intracerebral hemorrhage.

10. Edema from intracerebral hemorrhage: the role of thrombin.

1. Decompressive craniectomy with clot evacuation in large hemispheric hypertensive intracerebral hemorrhage.

2. [Recommendations of the European Stroke Initiative for the diagnosis and treatment of spontaneous intracerebral haemorrhage].

3. The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change.

Review 4. Pleiotropic role of PPARγ in intracerebral hemorrhage: an intricate system involving Nrf2, RXR, and NF-κB.

5. Nrf2 to pre-condition the brain against injury caused by products of hemolysis after ICH.

Review 6. The Role of Mast Cells in Intracerebral Hemorrhage.

Review 7. Minimally invasive endoscopic surgery for treatment of spontaneous intracerebral haematomas.

8. Increased expression of small heat shock protein αB-crystallin after intracerebral hemorrhage in adult rats.

9. TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice.

10. Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats.