Literature DB >> 23378859

Nrf2 to pre-condition the brain against injury caused by products of hemolysis after ICH.

Xiurong Zhao1, Jaroslaw Aronowski.   

Abstract

Brain damage caused by intracerebral hemorrhage (ICH) is mediated in part by the toxicity of extravascular blood deposited in brain parenchyma during the hematoma formation. In this paper we discuss the therapeutic benefits and potential mechanisms associated with the activation of transcription factor Nrf2 regarding its role in defending brain tissue against toxicity of blood, a component of secondary injury. We emphasize the pleiotropic capacity of Nrf2 as it recruits multiple pathways aiming at reducing deleterious effects of blood lysis products.

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Year:  2013        PMID： 23378859      PMCID： PMC3558942          DOI： 10.1007/s12975-012-0245-y

Source DB:  PubMed          Journal:  Transl Stroke Res        ISSN： 1868-4483            Impact factor:   6.829


  69 in total

1.  Upregulation of haptoglobin in reactive astrocytes after transient forebrain ischemia in rats.

Authors:  Mun-Yong Lee; Seong Yun Kim; Jeong-Sun Choi; Il-Ha Lee; Yun-Sik Choi; Jong Youl Jin; Seon-Joo Park; Ki-Wug Sung; Myung-Hoon Chun; In-Sook Kim
Journal:  J Cereb Blood Flow Metab       Date:  2002-10       Impact factor: 6.200

Review 2.  Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor.

Authors:  Dominik J Schaer; Abdu I Alayash; Paul W Buehler
Journal:  Antioxid Redox Signal       Date:  2007-07       Impact factor: 8.401

3.  Hemin binding and oxidation of lipoproteins in serum: mechanisms and effect on the interaction of LDL with human macrophages.

Authors:  G Camejo; C Halberg; A Manschik-Lundin; E Hurt-Camejo; B Rosengren; H Olsson; G I Hansson; G B Forsberg; B Ylhen
Journal:  J Lipid Res       Date:  1998-04       Impact factor: 5.922

4.  Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage.

Authors:  Jimin Wu; Ya Hua; Richard F Keep; Timothy Schallert; Julian T Hoff; Guohua Xi
Journal:  Brain Res       Date:  2002-10-25       Impact factor: 3.252

Review 5.  Hemopexin: structure, function, and regulation.

Authors:  Emanuela Tolosano; Fiorella Altruda
Journal:  DNA Cell Biol       Date:  2002-04       Impact factor: 3.311

Review 6.  Intracerebral haemorrhage: mechanisms of injury and therapeutic targets.

Authors:  Richard F Keep; Ya Hua; Guohua Xi
Journal:  Lancet Neurol       Date:  2012-06-13       Impact factor: 44.182

7.  Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products.

Authors:  Feng-Ping Huang; Guohua Xi; Richard F Keep; Ya Hua; Andrei Nemoianu; Julian T Hoff
Journal:  J Neurosurg       Date:  2002-02       Impact factor: 5.115

Review 8.  Molecular pathophysiology of cerebral hemorrhage: secondary brain injury.

Authors:  Jaroslaw Aronowski; Xiurong Zhao
Journal:  Stroke       Date:  2011-04-28       Impact factor: 7.914

9.  Hemoglobin-induced cytotoxicity in rat cerebral cortical neurons: caspase activation and oxidative stress.

Authors:  Xiaoying Wang; Tatsuro Mori; Toshihisa Sumii; Eng H Lo
Journal:  Stroke       Date:  2002-07       Impact factor: 7.914

10.  Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis.

Authors:  Emanuela Tolosano; Sharmila Fagoonee; Emilio Hirsch; Franklin G Berger; Heinz Baumann; Lorenzo Silengo; Fiorella Altruda
Journal:  Blood       Date:  2002-07-25       Impact factor: 22.113
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  25 in total

Review 1.  Neurovascular events after subarachnoid hemorrhage: focusing on subcellular organelles.

Authors:  Sheng Chen; Haijian Wu; Jiping Tang; Jianmin Zhang; John H Zhang
Journal:  Acta Neurochir Suppl       Date:  2015

Review 2.  Preventive and Protective Roles of Dietary Nrf2 Activators Against Central Nervous System Diseases.

Authors:  Yang Sun; Tuo Yang; Rehana K Leak; Jun Chen; Feng Zhang
Journal:  CNS Neurol Disord Drug Targets       Date:  2017       Impact factor: 4.388

Review 3.  Pleiotropic role of PPARγ in intracerebral hemorrhage: an intricate system involving Nrf2, RXR, and NF-κB.

Authors:  Xiu-Rong Zhao; Nicole Gonzales; Jaroslaw Aronowski
Journal:  CNS Neurosci Ther       Date:  2014-11-28       Impact factor: 5.243

Review 4.  Neonatal brain hemorrhage (NBH) of prematurity: translational mechanisms of the vascular-neural network.

Authors:  Tim Lekic; Damon Klebe; Roy Poblete; Paul R Krafft; William B Rolland; Jiping Tang; John H Zhang
Journal:  Curr Med Chem       Date:  2015       Impact factor: 4.530

5.  Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage.

Authors:  Loretta O Iniaghe; Paul R Krafft; Damon W Klebe; Eric K I Omogbai; John H Zhang; Jiping Tang
Journal:  Neurobiol Dis       Date:  2015-07-12       Impact factor: 5.996

6.  Dimethyl Fumarate Protects Brain From Damage Produced by Intracerebral Hemorrhage by Mechanism Involving Nrf2.

Authors:  Xiurong Zhao; Guanghua Sun; Jie Zhang; Shun-Ming Ting; Nicole Gonzales; Jaroslaw Aronowski
Journal:  Stroke       Date:  2015-05-14       Impact factor: 7.914

7.  Controversies and evolving new mechanisms in subarachnoid hemorrhage.

Authors:  Sheng Chen; Hua Feng; Prativa Sherchan; Damon Klebe; Gang Zhao; Xiaochuan Sun; Jianmin Zhang; Jiping Tang; John H Zhang
Journal:  Prog Neurobiol       Date:  2013-09-25       Impact factor: 11.685

8.  (-)-Epicatechin, a Natural Flavonoid Compound, Protects Astrocytes Against Hemoglobin Toxicity via Nrf2 and AP-1 Signaling Pathways.

Authors:  Xi Lan; Xiaoning Han; Qian Li; Jian Wang
Journal:  Mol Neurobiol       Date:  2016-11-18       Impact factor: 5.590

9.  Full steam ahead with remote ischemic conditioning for stroke.

Authors:  Richard F Keep; Michael M Wang; Jianming Xiang; Ya Hua; Guohua Xi
Journal:  Transl Stroke Res       Date:  2014-07-24       Impact factor: 6.829

Review 10.  Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke.

Authors:  Shuai Jiang; Chao Deng; Jianjun Lv; Chongxi Fan; Wei Hu; Shouyin Di; Xiaolong Yan; Zhiqiang Ma; Zhenxing Liang; Yang Yang
Journal:  Mol Neurobiol       Date:  2016-02-05       Impact factor: 5.590
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