Literature DB >> 1617465

Immobility-reducing effects of antidepressants in a genetic animal model of depression.

G D Schiller1, O Pucilowski, C Wienicke, D H Overstreet.   

Abstract

Chronic treatment with the tricyclic antidepressants imipramine (15 mg/kg) and desmethylimipramine (5 mg/kg) significantly reduced the exaggerated immobility normally exhibited by the Flinders Sensitive Line (FSL) rats in the Forced Swim Test. The control group, Flinders Resistant Line (FRL) rats were only slightly affected. In contrast, chronic treatment with the anticholinesterase diisopropyl fluorophosphate at doses known to down regulate muscarinic receptors did not alter swim test immobility in either FSL or FRL rats. Our findings support the validity of the FSL rats as an animal model of depression and suggest that serotonergic and/or noradrenergic, but not cholinergic mechanisms, may underlie the exaggerated immobility of the FSL rats.

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Year:  1992        PMID： 1617465     DOI： 10.1016/0361-9230(92)90267-2

Source DB:  PubMed          Journal:  Brain Res Bull        ISSN： 0361-9230            Impact factor:   4.077


  8 in total

Review 1.  Pathogenesis of depression: Insights from human and rodent studies.

Authors:  C Ménard; G E Hodes; S J Russo
Journal:  Neuroscience       Date:  2015-05-30       Impact factor: 3.590

2.  Differential responsiveness of inbred strains of rats to antidepressants in the forced swimming test: are Wistar Kyoto rats an animal model of subsensitivity to antidepressants?

Authors:  A Lahmame; A Armario
Journal:  Psychopharmacology (Berl)       Date:  1996-01       Impact factor: 4.530

3.  The possible use of hypoxic preconditioning for the prophylaxis of post-stress depressive episodes.

Authors:  E A Rybnikova; M O Samoilov; V I Mironova; E I Tyul'kova; S G Pivina; L A Vataeva; N E Ordyan; E Yu Abritalin; A I Kolchev
Journal:  Neurosci Behav Physiol       Date:  2008-09

4.  The reward system and maternal behavior in an animal model of depression: a microdialysis study.

Authors:  Yael Lavi-Avnon; Aron Weller; John P M Finberg; Iris Gispan-Herman; Noa Kinor; Yaakov Stern; Mariana Schroeder; Vered Gelber; S Yoav Bergman; David H Overstreet; Gal Yadid
Journal:  Psychopharmacology (Berl)       Date:  2007-10-11       Impact factor: 4.530

Review 5.  Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression.

Authors:  D H Overstreet; O Pucilowski; A H Rezvani; D S Janowsky
Journal:  Psychopharmacology (Berl)       Date:  1995-09       Impact factor: 4.530

6.  Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression.

Authors:  David H Overstreet; Joseph Hlavka; John P Feighner; Gabriela Nicolau; Jeffrey S Freed
Journal:  Psychopharmacology (Berl)       Date:  2004-09       Impact factor: 4.530

Review 7.  Repurposing Cholinesterase Inhibitors as Antidepressants? Dose and Stress-Sensitivity May Be Critical to Opening Possibilities.

Authors:  Paul J Fitzgerald; Pho J Hale; Anjesh Ghimire; Brendon O Watson
Journal:  Front Behav Neurosci       Date:  2021-01-14       Impact factor: 3.558

8.  Protracted effects of juvenile stressor exposure are mitigated by access to palatable food.

Authors:  Jennifer Christine MacKay; Jonathan Stewart James; Christian Cayer; Pamela Kent; Hymie Anisman; Zul Merali
Journal:  PLoS One       Date:  2014-05-06       Impact factor: 3.240
  8 in total

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