RATIONALE AND OBJECTIVES: Flinders sensitive line (FSL) rats, an animal model of depression, display a different pattern of maternal behavior compared to Sprague-Dawley (SD) controls. In this study, we examined the rewarding value of mother-infant interaction for FSL dams. MATERIALS AND METHODS: In the main study, we measured monoamine levels in the nucleus accumbens (NAc) of early postpartum FSL and SD dams during an interaction with pups, using the microdialysis technique. In addition, we compared the preference patterns of FSL and SD rats using the conditioned place preference paradigm, with pups as the unconditioned stimuli. RESULTS: Dopamine (DA) levels in dialysates from the NAc of SD dams but not FSL dams were elevated while interacting with pups but the metabolism of DA to dihydroxyphenylacetic acid was greater in FSL than in SD dams. While SD dams showed a conditioned preference for a region that was associated with SD pups, FSL dams did not show a preference for regions associated either with SD or FSL pups, but water deprived FSL rats demonstrated a preference to a region associated with water, eliminating an alternative explanation of learning deficit in FSL rats. CONCLUSIONS: Taken together, these results suggest that FSL dams are less rewarded by pups, compared to control dams.
RATIONALE AND OBJECTIVES: Flinders sensitive line (FSL) rats, an animal model of depression, display a different pattern of maternal behavior compared to Sprague-Dawley (SD) controls. In this study, we examined the rewarding value of mother-infant interaction for FSL dams. MATERIALS AND METHODS: In the main study, we measured monoamine levels in the nucleus accumbens (NAc) of early postpartum FSL and SD dams during an interaction with pups, using the microdialysis technique. In addition, we compared the preference patterns of FSL and SDrats using the conditioned place preference paradigm, with pups as the unconditioned stimuli. RESULTS:Dopamine (DA) levels in dialysates from the NAc of SD dams but not FSL dams were elevated while interacting with pups but the metabolism of DA to dihydroxyphenylacetic acid was greater in FSL than in SD dams. While SD dams showed a conditioned preference for a region that was associated with SD pups, FSL dams did not show a preference for regions associated either with SD or FSL pups, but water deprived FSL rats demonstrated a preference to a region associated with water, eliminating an alternative explanation of learning deficit in FSL rats. CONCLUSIONS: Taken together, these results suggest that FSL dams are less rewarded by pups, compared to control dams.
Authors: M Xu; T E Koeltzow; G T Santiago; R Moratalla; D C Cooper; X T Hu; N M White; A M Graybiel; F J White; S Tonegawa Journal: Neuron Date: 1997-10 Impact factor: 17.173
Authors: Laurel M Pritchard; Aaron D Logue; Scott Hayes; Jeffrey A Welge; Ming Xu; Jianhua Zhang; S Paul Berger; Neil M Richtand Journal: Neuropsychopharmacology Date: 2003-01 Impact factor: 7.853
Authors: Garret D Stuber; Mitchell F Roitman; Paul E M Phillips; Regina M Carelli; R Mark Wightman Journal: Neuropsychopharmacology Date: 2005-05 Impact factor: 7.853
Authors: Mariana Pereira; Andrew M Farrar; Jörg Hockemeyer; Christa E Müller; John D Salamone; Joan I Morrell Journal: Psychopharmacology (Berl) Date: 2010-09-17 Impact factor: 4.530
Authors: Tatiana A Shnitko; Kyla D Mace; Kaitlin M Sullivan; W Kyle Martin; Elizabeth H Andersen; Sarah K Williams Avram; Josephine M Johns; Donita L Robinson Journal: Behav Pharmacol Date: 2017-12 Impact factor: 2.293