Literature DB >> 16172374

Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice.

Brian J Cummings1, Nobuko Uchida, Stanley J Tamaki, Desirée L Salazar, Mitra Hooshmand, Robert Summers, Fred H Gage, Aileen J Anderson.   

Abstract

We report that prospectively isolated, human CNS stem cells grown as neurospheres (hCNS-SCns) survive, migrate, and express differentiation markers for neurons and oligodendrocytes after long-term engraftment in spinal cord-injured NOD-scid mice. hCNS-SCns engraftment was associated with locomotor recovery, an observation that was abolished by selective ablation of engrafted cells by diphtheria toxin. Remyelination by hCNS-SCns was found in both the spinal cord injury NOD-scid model and myelin-deficient shiverer mice. Moreover, electron microscopic evidence consistent with synapse formation between hCNS-SCns and mouse host neurons was observed. Glial fibrillary acidic protein-positive astrocytic differentiation was rare, and hCNS-SCns did not appear to contribute to the scar. These data suggest that hCNS-SCns may possess therapeutic potential for CNS injury and disease.

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Mesh：

Year:  2005        PMID： 16172374      PMCID： PMC1216836          DOI： 10.1073/pnas.0507063102

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  38 in total

1.  Differentiation of engrafted neuronal-restricted precursor cells is inhibited in the traumatically injured spinal cord.

Authors:  Qi-Lin Cao; Russell M Howard; Jessica B Dennison; Scott R Whittemore
Journal:  Exp Neurol       Date:  2002-10       Impact factor: 5.330

2.  Expression of chemokine receptors CXCR4, CCR2, CCR5 and CX3CR1 in neural progenitor cells isolated from the subventricular zone of the adult rat brain.

Authors:  Jun Feng Ji; Bei Ping He; S Thameem Dheen; Samuel Sam Wah Tay
Journal:  Neurosci Lett       Date:  2004-01-30       Impact factor: 3.046

3.  Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils.

Authors:  Satoru Ishibashi; Masanori Sakaguchi; Toshihiko Kuroiwa; Mami Yamasaki; Yonehiro Kanemura; Ichinose Shizuko; Takuya Shimazaki; Masafumi Onodera; Hideyuki Okano; Hidehiro Mizusawa
Journal:  J Neurosci Res       Date:  2004-10-15       Impact factor: 4.164

4.  Region-specific generation of functional neurons from naive embryonic stem cells in adult brain.

Authors:  Tibor Harkany; Michael Andäng; Hylke Jan Kingma; Tamás J Görcs; Carl D Holmgren; Yuri Zilberter; Patrik Ernfors
Journal:  J Neurochem       Date:  2004-03       Impact factor: 5.372

5.  Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury.

Authors:  Hans S Keirstead; Gabriel Nistor; Giovanna Bernal; Minodora Totoiu; Frank Cloutier; Kelly Sharp; Oswald Steward
Journal:  J Neurosci       Date:  2005-05-11       Impact factor: 6.167

6.  Xenotransplantation of stem/progenitor cells from human fetal brain to adult rats with spinal trauma.

Authors:  G A Stepanov; D O Karpenko; M A Aleksandrova; O V Podgornyi; R A Poltavtseva; A V Pevishchin; M V Marey; G T Sukhikh
Journal:  Bull Exp Biol Med       Date:  2003-04       Impact factor: 0.804

7.  Human umbilical cord blood stem cells infusion in spinal cord injury: engraftment and beneficial influence on behavior.

Authors:  Samuel Saporta; Jong-Joong Kim; Alison E Willing; Eugene S Fu; Cyndy D Davis; Paul R Sanberg
Journal:  J Hematother Stem Cell Res       Date:  2003-06

8.  Functional integration of embryonic stem cell-derived neurons in vivo.

Authors:  Marius Wernig; Felix Benninger; Tanja Schmandt; Monika Rade; Kerry L Tucker; Heinrich Büssow; Heinz Beck; Oliver Brüstle
Journal:  J Neurosci       Date:  2004-06-02       Impact factor: 6.167

9.  Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex.

Authors:  S Kelly; T M Bliss; A K Shah; G H Sun; M Ma; W C Foo; J Masel; M A Yenari; I L Weissman; N Uchida; T Palmer; G K Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-27       Impact factor: 11.205

10.  Adult neural progenitor cell grafts survive after acute spinal cord injury and integrate along axonal pathways.

Authors:  Maurice Vroemen; Ludwig Aigner; Juergen Winkler; Norbert Weidner
Journal:  Eur J Neurosci       Date:  2003-08       Impact factor: 3.386
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  268 in total

Review 1.  The dark side of neuroplasticity.

Authors:  Arthur Brown; Lynne C Weaver
Journal:  Exp Neurol       Date:  2011-11-12       Impact factor: 5.330

2.  Microtissue engineered constructs with living axons for targeted nervous system reconstruction.

Authors:  D Kacy Cullen; Min D Tang-Schomer; Laura A Struzyna; Ankur R Patel; Victoria E Johnson; John A Wolf; Douglas H Smith
Journal:  Tissue Eng Part A       Date:  2012-08-17       Impact factor: 3.845

Review 3.  Neural regeneration: lessons from regenerating and non-regenerating systems.

Authors:  Leonardo M R Ferreira; Elisa M Floriddia; Giorgia Quadrato; Simone Di Giovanni
Journal:  Mol Neurobiol       Date:  2012-06-21       Impact factor: 5.590

Review 4.  Neural plasticity of development and learning.

Authors:  Adriana Galván
Journal:  Hum Brain Mapp       Date:  2010-06       Impact factor: 5.038

5.  Nanofiber matrices promote the neuronal differentiation of human embryonic stem cell-derived neural precursors in vitro.

Authors:  Vasiliki Mahairaki; Shawn H Lim; Gregory T Christopherson; Leyan Xu; Igor Nasonkin; Christopher Yu; Hai-Quan Mao; Vassilis E Koliatsos
Journal:  Tissue Eng Part A       Date:  2010-12-18       Impact factor: 3.845

Review 6.  Separation of neural stem cells by whole cell membrane capacitance using dielectrophoresis.

Authors:  Tayloria N G Adams; Alan Y L Jiang; Prema D Vyas; Lisa A Flanagan
Journal:  Methods       Date:  2017-08-31       Impact factor: 3.608

Review 7.  Translational spinal cord injury research: preclinical guidelines and challenges.

Authors:  Paul J Reier; Michael A Lane; Edward D Hall; Y D Teng; Dena R Howland
Journal:  Handb Clin Neurol       Date:  2012

Review 8.  Pluripotent stem cells in regenerative medicine: challenges and recent progress.

Authors:  Viviane Tabar; Lorenz Studer
Journal:  Nat Rev Genet       Date:  2014-02       Impact factor: 53.242

9.  A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury.

Authors:  Nishanth Lakshman; Wenjun Xu; Cindi M Morshead
Journal:  J Vis Exp       Date:  2018-09-13       Impact factor: 1.355

10.  Differentiation of V2a interneurons from human pluripotent stem cells.

Authors:  Jessica C Butts; Dylan A McCreedy; Jorge Alexis Martinez-Vargas; Frederico N Mendoza-Camacho; Tracy A Hookway; Casey A Gifford; Praveen Taneja; Linda Noble-Haeusslein; Todd C McDevitt
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-24       Impact factor: 11.205
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