Yaeko Kobayashi1, Futoshi Akiyama, Katuhiko Hasumi. 1. Department of Gynecology and Pathology, Cancer Institute Hospital, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170, Japan. yaekoko@musashino.jrc.or.jp
Abstract
BACKGROUND: The standard therapy for invasive uterine cervical cancer causes loss of the woman's fertility. We report a successful pregnancy in a patient who desired fertility-sparing management of invasive cervical cancer and was treated with systemic chemotherapy and conization. CASE: A 28-year-old nulliparous woman was diagnosed with a large 30-mm-diameter stage IB1 squamous cell carcinoma of the uterine cervix. The patient received 4 courses of systemic chemotherapy with consecutive low-dose BOMP (cisplatin, bleomycin, vincristine and mitomycin C), which produced complete pathological response assessed by examination of specimens from conization. Two years later, the patient became pregnant, resulting in the birth of a healthy infant. CONCLUSION: This procedure is one method of conservative management to preserve fertility in invasive cervical cancer.
BACKGROUND: The standard therapy for invasive uterine cervical cancer causes loss of the woman's fertility. We report a successful pregnancy in a patient who desired fertility-sparing management of invasive cervical cancer and was treated with systemic chemotherapy and conization. CASE: A 28-year-old nulliparous woman was diagnosed with a large 30-mm-diameter stage IB1squamous cell carcinoma of the uterine cervix. The patient received 4 courses of systemic chemotherapy with consecutive low-dose BOMP (cisplatin, bleomycin, vincristine and mitomycin C), which produced complete pathological response assessed by examination of specimens from conization. Two years later, the patient became pregnant, resulting in the birth of a healthy infant. CONCLUSION: This procedure is one method of conservative management to preserve fertility in invasive cervical cancer.
Authors: Francesco Fanfani; Fabio Landoni; Maria Lucia Gagliardi; Anna Fagotti; Eleonora Preti; Maria Cristina Moruzzi; Giorgia Monterossi; Giovanni Scambia Journal: J Reprod Infertil Date: 2014-01