| Literature DB >> 16170323 |
R Andres Floto1, Menna R Clatworthy, Karen R Heilbronn, Dalya R Rosner, Paul A MacAry, Angela Rankin, Paul J Lehner, Willem H Ouwehand, Janet M Allen, Nicholas A Watkins, Kenneth G C Smith.
Abstract
Dysfunction of receptors for IgG (FcgammaRs) has been thought to be involved in the pathogenesis of systemic lupus erythematosus (SLE). We show that a recently described SLE-associated polymorphism of FcgammaRIIb (FcgammaRIIbT(232)), encoding a single transmembrane amino acid substitution, is functionally impaired. FcgammaRIIbT(232) is unable to inhibit activatory receptors because it is excluded from sphingolipid rafts, resulting in the unopposed proinflammatory signaling thought to promote SLE.Entities:
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Year: 2005 PMID： 16170323 DOI： 10.1038/nm1288
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440