Literature DB >> 17115158

Activating and inhibitory FcgammaRs in autoimmune disorders.

Falk Nimmerjahn1.   

Abstract

Autoimmune disorders are characterized by the destruction of self-tissues by the immune system. Multiple checkpoints are in place to prevent autoreactivity under normal circumstances. Coexpression of activating and inhibitory Fc receptors (FcR) represents such a checkpoint by establishing a threshold for immune cell activation. In many human autoimmune diseases, however, balanced FcR expression is disturbed. Analysis of murine model systems provides strong evidence that aberrant FcR expression can result in uncontrolled immune responses and the initiation of autoimmune disease. This review will summarize this data and explain how this information might be used to better understand human autoimmune diseases and to develop novel therapeutic strategies.

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Year:  2006        PMID： 17115158     DOI： 10.1007/s00281-006-0052-1

Source DB:  PubMed          Journal:  Springer Semin Immunopathol        ISSN： 0344-4325


  171 in total

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Journal:  Hum Mol Genet       Date:  2005-08-22       Impact factor: 6.150

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Journal:  Blood       Date:  2002-02-01       Impact factor: 22.113

4.  Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor.

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Journal:  Science       Date:  2001-01-19       Impact factor: 47.728

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Journal:  Immunity       Date:  1996-08       Impact factor: 31.745

6.  Physical and functional association of Fc alpha R with protein tyrosine kinase Lyn.

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Journal:  Blood       Date:  1998-01-15       Impact factor: 22.113

7.  Polymorphism of the FcgammaRIIalpha IgG receptor in patients with lupus nephritis and glomerulopathy.

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Journal:  J Rheumatol       Date:  2006-03       Impact factor: 4.666

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Journal:  Nature       Date:  1996-01-25       Impact factor: 49.962

9.  Murine IgG1 complexes trigger immune effector functions predominantly via Fc gamma RIII (CD16).

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Journal:  J Immunol       Date:  1998-09-15       Impact factor: 5.422

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Journal:  J Exp Med       Date:  1996-12-01       Impact factor: 14.307
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  26 in total

Review 1.  Use of mouse models to study the mechanisms and consequences of RBC clearance.

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Journal:  Vox Sang       Date:  2010-03-21       Impact factor: 2.144

2.  The chicken leukocyte receptor complex encodes a primordial, activating, high-affinity IgY Fc receptor.

Authors:  Birgit C Viertlboeck; Sonja Schweinsberg; Matthias A Hanczaruk; Ramona Schmitt; Louis Du Pasquier; Friedrich W Herberg; Thomas W Göbel
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-02       Impact factor: 11.205

3.  The SCHOOL of nature: I. Transmembrane signaling.

Authors:  Alexander B Sigalov
Journal:  Self Nonself       Date:  2010-01

Review 4.  Targeting B cells and autoantibodies in the therapy of autoimmune diseases.

Authors:  Daniela Kao; Anja Lux; Inessa Schwab; Falk Nimmerjahn
Journal:  Semin Immunopathol       Date:  2014-04-29       Impact factor: 9.623

Review 5.  Mechanisms of Autoantibody-Induced Pathology.

Authors:  Ralf J Ludwig; Karen Vanhoorelbeke; Frank Leypoldt; Ziya Kaya; Katja Bieber; Sandra M McLachlan; Lars Komorowski; Jie Luo; Otavio Cabral-Marques; Christoph M Hammers; Jon M Lindstrom; Peter Lamprecht; Andrea Fischer; Gabriela Riemekasten; Claudia Tersteeg; Peter Sondermann; Basil Rapoport; Klaus-Peter Wandinger; Christian Probst; Asmaa El Beidaq; Enno Schmidt; Alan Verkman; Rudolf A Manz; Falk Nimmerjahn
Journal:  Front Immunol       Date:  2017-05-31       Impact factor: 7.561

6.  Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.

Authors:  Anil K Chauhan; Chen Chen; Terry L Moore; Richard J DiPaolo
Journal:  J Biol Chem       Date:  2015-01-02       Impact factor: 5.157

Review 7.  The promise and challenges of immune agonist antibody development in cancer.

Authors:  Patrick A Mayes; Kenneth W Hance; Axel Hoos
Journal:  Nat Rev Drug Discov       Date:  2018-06-15       Impact factor: 84.694

8.  Fcgamma receptors modulate pulmonary inflammation by activating innate immune cells in murine hypersensitivity pneumonitis.

Authors:  Hyo Jin Park; Hye Sung Kim; Doo Hyun Chung
Journal:  Immune Netw       Date:  2010-02-28       Impact factor: 6.303

9.  FCGR2C polymorphisms associate with HIV-1 vaccine protection in RV144 trial.

Authors:  Shuying S Li; Peter B Gilbert; Georgia D Tomaras; Gustavo Kijak; Guido Ferrari; Rasmi Thomas; Chul-Woo Pyo; Susan Zolla-Pazner; David Montefiori; Hua-Xin Liao; Gary Nabel; Abraham Pinter; David T Evans; Raphael Gottardo; James Y Dai; Holly Janes; Daryl Morris; Youyi Fong; Paul T Edlefsen; Fusheng Li; Nicole Frahm; Michael D Alpert; Heather Prentice; Supachai Rerks-Ngarm; Punnee Pitisuttithum; Jaranit Kaewkungwal; Sorachai Nitayaphan; Merlin L Robb; Robert J O'Connell; Barton F Haynes; Nelson L Michael; Jerome H Kim; M Juliana McElrath; Daniel E Geraghty
Journal:  J Clin Invest       Date:  2014-08-08       Impact factor: 14.808

10.  Fcγ receptors and toll-like receptor 9 synergize to drive immune complex-induced dendritic cell maturation.

Authors:  Nicole L J Nelson; Cheryl M Zajd; Michelle R Lennartz; Edmund J Gosselin
Journal:  Cell Immunol       Date:  2019-08-03       Impact factor: 4.868
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