OBJECTIVES: To compare the sensitivity, specificity, and total accuracy of an HbA1c of > or =6.5% in the detection of hyperglycemia (PPHG) relative to those of a fasting blood glucose (FBG) of > or =7.0 mmol/L. METHODS: A total of 6,010 subjects (2,987 men and 3,023 women) living or working in Kasugai, Japan, underwent a medical checkup at Kasugai City Medical Care Center between April 2001 and March 2002. For the 91 subjects who had either a FBG of > or =7.0 mmol/L or an HbA1c of > or =6.5%, a 75-g oral glucose tolerance test was performed to confirm or exclude PPHG. We calculated the true- and false-positive odds ratios to evaluate the sensitivity and specificity of HbA1c relative to FBG, and compared the overall accuracy by calculating the conditional relative odds ratio (CROR). RESULTS: Among the 91 subjects, the true- and false-positive odds ratios were 0.43 (95% CI 0.26-0.69) and 0.40 (0.13-1.27) (Fisher's exact test, P < .090), respectively; the CROR was 1.07 (95% CI 0.30-3.75). CONCLUSIONS: Although the HbA1c test was marginally more specific but less sensitive than the FBG test, at the given cutoff points the accuracies of two tests were equivalent.
OBJECTIVES: To compare the sensitivity, specificity, and total accuracy of an HbA1c of > or =6.5% in the detection of hyperglycemia (PPHG) relative to those of a fasting blood glucose (FBG) of > or =7.0 mmol/L. METHODS: A total of 6,010 subjects (2,987 men and 3,023 women) living or working in Kasugai, Japan, underwent a medical checkup at Kasugai City Medical Care Center between April 2001 and March 2002. For the 91 subjects who had either a FBG of > or =7.0 mmol/L or an HbA1c of > or =6.5%, a 75-g oral glucose tolerance test was performed to confirm or exclude PPHG. We calculated the true- and false-positive odds ratios to evaluate the sensitivity and specificity of HbA1c relative to FBG, and compared the overall accuracy by calculating the conditional relative odds ratio (CROR). RESULTS: Among the 91 subjects, the true- and false-positive odds ratios were 0.43 (95% CI 0.26-0.69) and 0.40 (0.13-1.27) (Fisher's exact test, P < .090), respectively; the CROR was 1.07 (95% CI 0.30-3.75). CONCLUSIONS: Although the HbA1c test was marginally more specific but less sensitive than the FBG test, at the given cutoff points the accuracies of two tests were equivalent.
Authors: Michael Bergman; Muhammad Abdul-Ghani; Ralph A DeFronzo; Melania Manco; Giorgio Sesti; Teresa Vanessa Fiorentino; Antonio Ceriello; Mary Rhee; Lawrence S Phillips; Stephanie Chung; Celeste Cravalho; Ram Jagannathan; Louis Monnier; Claude Colette; David Owens; Cristina Bianchi; Stefano Del Prato; Mariana P Monteiro; João Sérgio Neves; Jose Luiz Medina; Maria Paula Macedo; Rogério Tavares Ribeiro; João Filipe Raposo; Brenda Dorcely; Nouran Ibrahim; Martin Buysschaert Journal: Diabetes Res Clin Pract Date: 2020-06-01 Impact factor: 5.602
Authors: Jose Lopez-Lopez; Jennifer Garay; Edwin Wandurraga; Paul A Camacho; Fernando Higuera-Escalante; Daniel Cohen; Patricio Lopez-Jaramillo Journal: PLoS One Date: 2018-04-13 Impact factor: 3.240
Authors: Roy William Mayega; David Guwatudde; Fredrick Makumbi; Frederick Nelson Nakwagala; Stefan Peterson; Goran Tomson; Claes-Goran Ostenson Journal: PLoS One Date: 2013-08-14 Impact factor: 3.240