Literature DB >> 16165179

Ribosome-inactivating proteins and other lectins from Adenia (Passifloraceae).

Emanuele Pelosi1, Chiara Lubelli, Letizia Polito, Luigi Barbieri, Andrea Bolognesi, Fiorenzo Stirpe.   

Abstract

The caudices of 10 Adenia species contain galactose-binding lectins that were purified by affinity chromatography. All lectins but three agglutinate human erythrocytes. Six lectins consist of two unequal chains, which can be separated by reduction, and inhibit protein synthesis both by a rabbit reticulocyte lysate and by HeLa and Raji cells. The lectins from A. goetzii, A. lanceolata and A. stenodactyla had the highest cytotoxicity, inhibiting cell protein synthesis with IC50s (concentration inhibiting by 50%) below 0.1 ng/ml, and deadenylate DNA, thus being type 2 ribosome-inactivating proteins.

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Year:  2005        PMID： 16165179     DOI： 10.1016/j.toxicon.2005.07.008

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  9 in total

1.  Crystallization and preliminary X-ray diffraction data analysis of stenodactylin, a highly toxic type 2 ribosome-inactivating protein from Adenia stenodactyla.

Authors:  Giovanna Tosi; Simona Fermani; Giuseppe Falini; Letizia Polito; Massimo Bortolotti; Andrea Bolognesi
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-12-25

2.  Purification, characterization and fine sugar specificity of a N-Acetylgalactosamine specific lectin from Adenia hondala.

Authors:  Mamta Sharma; Prajna Hegde; Kavita Hiremath; Vishwanath Reddy H; A S Kamalanathan; Bale M Swamy; Shashikala R Inamdar
Journal:  Glycoconj J       Date:  2018-10-10       Impact factor: 2.916

Review 3.  Ribosome-inactivating and related proteins.

Authors:  Joachim Schrot; Alexander Weng; Matthias F Melzig
Journal:  Toxins (Basel)       Date:  2015-05-08       Impact factor: 4.546

Review 4.  Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy.

Authors:  Roger Gilabert-Oriol; Alexander Weng; Benedicta von Mallinckrodt; Matthias F Melzig; Hendrik Fuchs; Mayank Thakur
Journal:  Curr Pharm Des       Date:  2014       Impact factor: 3.116

5.  Early Response to the Plant Toxin Stenodactylin in Acute Myeloid Leukemia Cells Involves Inflammatory and Apoptotic Signaling.

Authors:  Daniele Mercatelli; Massimo Bortolotti; Vibeke Andresen; André Sulen; Letizia Polito; Bjørn Tore Gjertsen; Andrea Bolognesi
Journal:  Front Pharmacol       Date:  2020-05-08       Impact factor: 5.810

Review 6.  Hyperuricaemia, Xanthine Oxidoreductase and Ribosome-Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research.

Authors:  Andrea Bolognesi; Massimo Bortolotti; Maria Giulia Battelli; Letizia Polito
Journal:  Molecules       Date:  2017-01-27       Impact factor: 4.411

7.  In Vitro Phytotherapeutic Properties of Aqueous Extracted Adenia viridiflora Craib. towards Civilization Diseases.

Authors:  Werawat Wannasaksri; Nattira On-Nom; Chaowanee Chupeerach; Piya Temviriyanukul; Somsri Charoenkiatkul; Uthaiwan Suttisansanee
Journal:  Molecules       Date:  2021-02-18       Impact factor: 4.411

8.  Kirkiin: A New Toxic Type 2 Ribosome-Inactivating Protein from the Caudex of Adenia kirkii.

Authors:  Massimo Bortolotti; Stefania Maiello; José M Ferreras; Rosario Iglesias; Letizia Polito; Andrea Bolognesi
Journal:  Toxins (Basel)       Date:  2021-01-22       Impact factor: 4.546

9.  Sequence, Structure, and Binding Site Analysis of Kirkiin in Comparison with Ricin and Other Type 2 RIPs.

Authors:  Stefania Maiello; Rosario Iglesias; Letizia Polito; Lucía Citores; Massimo Bortolotti; José M Ferreras; Andrea Bolognesi
Journal:  Toxins (Basel)       Date:  2021-12-03       Impact factor: 4.546
  9 in total

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