BACKGROUND: The presence of diabetes mellitus (DM) in chronic hemodialysis (CHD) patients has potential to increase body protein losses and muscle wasting. METHODS: In this study, we examined whole-body and skeletal muscle protein metabolism in 6 CHD patients with type 2 (T2) DM (2 male, 44.4 +/- 6.1 years old, 2 white/4 African American HbA(1)C = 9.5 +/- 1.1%), and 6 non-DM CHD patients (2 male, 43.3 +/- 6.7 years old, 2 white/4 African American) in a fasting state, using a primed-constant infusion of L-(1-(13)C) leucine and L-(ring-(2)H(5)) phenylalanine. RESULTS: CHD patients with T2DM had significantly increased (83%) skeletal muscle protein breakdown (137 +/- 27 vs. 75 +/- 25 microg/100 mL/min). There was no significant difference in muscle protein synthesis between groups (78 +/- 27 vs. 66 +/- 21 microg/100 mL/min, for DM and non-DM respectively), resulting in significantly more negative net protein balance in the muscle compartment in the DM group (-59 +/- 4 vs. -9 +/- 6 microg/100 mL/min, P < 0.05). A similar trend was observed in whole-body protein synthesis and breakdown. Plasma glucose levels were 113 +/- 16 and 71 +/- 2 mg/dL, P < 0.05, and insulin levels were 25.3 +/- 9.6 and 7.3 +/- 1.0 uU/mL, for DM versus non-DM, respectively, P < 0.05. No significant differences between DM and non-DM were found in other metabolic hormones. CONCLUSION: The results of this study demonstrate that CHD patients with T2DM under a suboptimal metabolic control display accelerated muscle protein loss compared with a matched group of non-DM CHD patients.
BACKGROUND: The presence of diabetes mellitus (DM) in chronic hemodialysis (CHD) patients has potential to increase body protein losses and muscle wasting. METHODS: In this study, we examined whole-body and skeletal muscle protein metabolism in 6 CHD patients with type 2 (T2) DM (2 male, 44.4 +/- 6.1 years old, 2 white/4 African American HbA(1)C = 9.5 +/- 1.1%), and 6 non-DM CHDpatients (2 male, 43.3 +/- 6.7 years old, 2 white/4 African American) in a fasting state, using a primed-constant infusion of L-(1-(13)C) leucine and L-(ring-(2)H(5)) phenylalanine. RESULTS: CHD patients with T2DM had significantly increased (83%) skeletal muscle protein breakdown (137 +/- 27 vs. 75 +/- 25 microg/100 mL/min). There was no significant difference in muscle protein synthesis between groups (78 +/- 27 vs. 66 +/- 21 microg/100 mL/min, for DM and non-DM respectively), resulting in significantly more negative net protein balance in the muscle compartment in the DM group (-59 +/- 4 vs. -9 +/- 6 microg/100 mL/min, P < 0.05). A similar trend was observed in whole-body protein synthesis and breakdown. Plasma glucose levels were 113 +/- 16 and 71 +/- 2 mg/dL, P < 0.05, and insulin levels were 25.3 +/- 9.6 and 7.3 +/- 1.0 uU/mL, for DM versus non-DM, respectively, P < 0.05. No significant differences between DM and non-DM were found in other metabolic hormones. CONCLUSION: The results of this study demonstrate that CHD patients with T2DM under a suboptimal metabolic control display accelerated muscle protein loss compared with a matched group of non-DM CHDpatients.
Authors: Laura D Byham-Gray; J Scott Parrott; Emily N Peters; Susan Gould Fogerite; Rosa K Hand; Sean Ahrens; Andrea Fleisch Marcus; Justin J Fiutem Journal: JPEN J Parenter Enteral Nutr Date: 2017-12-19 Impact factor: 4.016
Authors: Serpil M Deger; Adriana M Hung; Jorge L Gamboa; Edward D Siew; Charles D Ellis; Cindy Booker; Feng Sha; Haiming Li; Aihua Bian; Thomas G Stewart; Roy Zent; William E Mitch; Naji N Abumrad; T Alp Ikizler Journal: JCI Insight Date: 2017-11-16
Authors: Katharina M Espe; Jens Raila; Andrea Henze; Katja Blouin; Andreas Schneider; Daniel Schmiedeke; Vera Krane; Stefan Pilz; Florian J Schweigert; Berthold Hocher; Christoph Wanner; Christiane Drechsler Journal: Clin J Am Soc Nephrol Date: 2013-01-18 Impact factor: 8.237
Authors: Serpil Muge Deger; Adriana M Hung; Charles D Ellis; Cindy Booker; Aihua Bian; Guanhua Chen; Naji N Abumrad; T Alp Ikizler Journal: Clin J Am Soc Nephrol Date: 2016-06-08 Impact factor: 8.237
Authors: Serpil M Deger; Jennifer R Hewlett; Jorge Gamboa; Charles D Ellis; Adriana M Hung; Edward D Siew; Cindy Mamnungu; Feng Sha; Aihua Bian; Thomas G Stewart; Naji N Abumrad; T Alp Ikizler Journal: Am J Physiol Endocrinol Metab Date: 2018-06-12 Impact factor: 4.310