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Literature DB >> 16159793

The MutS C terminus is essential for mismatch repair activity in vivo.

Melissa A Calmann¹, Anetta Nowosielska, M G Marinus.

Abstract

An Escherichia coli K-12 strain was constructed with a chromosomal deletion (mutSdelta800) in the mutS gene that produced the removal of the C-terminal 53 amino acids which are not present in the MutS crystal structure. This strain has a MutS null phenotype for mutation avoidance, anti-recombination, and sensitivity to cytotoxic agents in a dam mutant background.

Entities: Gene Species

Mesh：

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Year: 2005 PMID： 16159793 PMCID： PMC1236653 DOI： 10.1128/JB.187.18.6577-6579.2005

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

16 in total

1. Disruption of the helix-u-turn-helix motif of MutS protein: loss of subunit dimerization, mismatch binding and ATP hydrolysis.

Authors: I Biswas; G Obmolova; M Takahashi; A Herr; M A Newman; W Yang; P Hsieh
Journal: J Mol Biol Date: 2001-01-26 Impact factor: 5.469

Review 2. DNA mismatch repair: molecular mechanisms and biological function.

Authors: Mark J Schofield; Peggy Hsieh
Journal: Annu Rev Microbiol Date: 2003 Impact factor: 15.500

3. Assembly and molecular activities of the MutS tetramer.

Authors: Keith P Bjornson; Leonard J Blackwell; Harvey Sage; Celia Baitinger; Dwayne Allen; Paul Modrich
Journal: J Biol Chem Date: 2003-06-25 Impact factor: 5.157

4. Mismatch correction at O6-methylguanine residues in E. coli DNA.

Authors: P Karran; M G Marinus
Journal: Nature Date: 1982-04-29 Impact factor: 49.962

5. Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA.

Authors: G Obmolova; C Ban; P Hsieh; W Yang
Journal: Nature Date: 2000-10-12 Impact factor: 49.962

Review 6. DNA mismatch repair and mutation avoidance pathways.

Authors: Thomas M Marti; Christophe Kunz; Oliver Fleck
Journal: J Cell Physiol Date: 2002-04 Impact factor: 6.384

7. Mismatch repair of cis-diamminedichloroplatinum(II)-induced DNA damage.

Authors: R J Fram; P S Cusick; J M Wilson; M G Marinus
Journal: Mol Pharmacol Date: 1985-07 Impact factor: 4.436

8. N-Methyl-N'-nitro-N-nitrosoguanidine sensitivity of E. coli mutants deficient in DNA methylation and mismatch repair.

Authors: M Jones; R Wagner
Journal: Mol Gen Genet Date: 1981

9. Separation of mutation avoidance and antirecombination functions in an Escherichia coli mutS mutant.

Authors: Melissa A Calmann; Anetta Nowosielska; M G Marinus
Journal: Nucleic Acids Res Date: 2005-02-24 Impact factor: 16.971

10. Lambda Red-mediated recombinogenic engineering of enterohemorrhagic and enteropathogenic E. coli.

Authors: Kenan C Murphy; Kenneth G Campellone
Journal: BMC Mol Biol Date: 2003-12-13 Impact factor: 2.946

12 in total

1. Truncation of the MSH2 C-terminal 60 amino acids disrupts effective DNA mismatch repair and is causative for Lynch syndrome.

Authors: Eva Wielders; Elly Delzenne-Goette; Rob Dekker; Martin van der Valk; Hein Te Riele
Journal: Fam Cancer Date: 2017-04 Impact factor: 2.375

The MutS C terminus is essential for mismatch repair activity in vivo.

1. Disruption of the helix-u-turn-helix motif of MutS protein: loss of subunit dimerization, mismatch binding and ATP hydrolysis.

Review 2. DNA mismatch repair: molecular mechanisms and biological function.

3. Assembly and molecular activities of the MutS tetramer.

4. Mismatch correction at O6-methylguanine residues in E. coli DNA.

5. Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA.

Review 6. DNA mismatch repair and mutation avoidance pathways.

7. Mismatch repair of cis-diamminedichloroplatinum(II)-induced DNA damage.

8. N-Methyl-N'-nitro-N-nitrosoguanidine sensitivity of E. coli mutants deficient in DNA methylation and mismatch repair.

9. Separation of mutation avoidance and antirecombination functions in an Escherichia coli mutS mutant.

10. Lambda Red-mediated recombinogenic engineering of enterohemorrhagic and enteropathogenic E. coli.

1. Truncation of the MSH2 C-terminal 60 amino acids disrupts effective DNA mismatch repair and is causative for Lynch syndrome.

2. DnaN clamp zones provide a platform for spatiotemporal coupling of mismatch detection to DNA replication.

3. Beta clamp directs localization of mismatch repair in Bacillus subtilis.

Review 4. DNA mismatch repair: molecular mechanism, cancer, and ageing.

5. Mismatch repair inhibits homeologous recombination via coordinated directional unwinding of trapped DNA structures.

6. DNA Mismatch Repair.

7. The role of nucleotide cofactor binding in cooperativity and specificity of MutS recognition.

8. DNA mismatch repair in eukaryotes and bacteria.

9. Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops.

10. Endonuclease-independent DNA mismatch repair processes on the lagging strand.