Literature DB >> 14527292

DNA mismatch repair: molecular mechanisms and biological function.

Mark J Schofield1, Peggy Hsieh.   

Abstract

DNA mismatch repair (MMR) guards the integrity of the genome in virtually all cells. It contributes about 1000-fold to the overall fidelity of replication and targets mispaired bases that arise through replication errors, during homologous recombination, and as a result of DNA damage. Cells deficient in MMR have a mutator phenotype in which the rate of spontaneous mutation is greatly elevated, and they frequently exhibit microsatellite instability at mono- and dinucleotide repeats. The importance of MMR in mutation avoidance is highlighted by the finding that defects in MMR predispose individuals to hereditary nonpolyposis colorectal cancer. In addition to its role in postreplication repair, the MMR machinery serves to police homologous recombination events and acts as a barrier to genetic exchange between species.

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Year:  2003        PMID： 14527292     DOI： 10.1146/annurev.micro.57.030502.090847

Source DB:  PubMed          Journal:  Annu Rev Microbiol        ISSN： 0066-4227            Impact factor:   15.500


  191 in total

1.  Mutations in the Bacillus subtilis beta clamp that separate its roles in DNA replication from mismatch repair.

Authors:  Nicole M Dupes; Brian W Walsh; Andrew D Klocko; Justin S Lenhart; Heather L Peterson; David A Gessert; Cassie E Pavlick; Lyle A Simmons
Journal:  J Bacteriol       Date:  2010-05-07       Impact factor: 3.490

2.  Asymmetric ATP binding and hydrolysis activity of the Thermus aquaticus MutS dimer is key to modulation of its interactions with mismatched DNA.

Authors:  Edwin Antony; Manju M Hingorani
Journal:  Biochemistry       Date:  2004-10-19       Impact factor: 3.162

3.  A study on mutational dynamics of simple sequence repeats in relation to mismatch repair system in prokaryotic genomes.

Authors:  Pankaj Kumar; H A Nagarajaram
Journal:  J Mol Evol       Date:  2012-03-14       Impact factor: 2.395

Review 4.  DNA motifs that sculpt the bacterial chromosome.

Authors:  Fabrice Touzain; Marie-Agnès Petit; Sophie Schbath; Meriem El Karoui
Journal:  Nat Rev Microbiol       Date:  2011-01       Impact factor: 60.633

5.  Mismatch repair causes the dynamic release of an essential DNA polymerase from the replication fork.

Authors:  Andrew D Klocko; Jeremy W Schroeder; Brian W Walsh; Justin S Lenhart; Margery L Evans; Lyle A Simmons
Journal:  Mol Microbiol       Date:  2011-09-30       Impact factor: 3.501

Review 6.  Biological Processes Discovered by High-Throughput Sequencing.

Authors:  Brian J Reon; Anindya Dutta
Journal:  Am J Pathol       Date:  2016-01-30       Impact factor: 4.307

7.  The mismatch repair system protects against intergenerational GAA repeat instability in a Friedreich ataxia mouse model.

Authors:  Vahid Ezzatizadeh; Ricardo Mouro Pinto; Chiranjeevi Sandi; Madhavi Sandi; Sahar Al-Mahdawi; Hein Te Riele; Mark A Pook
Journal:  Neurobiol Dis       Date:  2012-01-20       Impact factor: 5.996

8.  Role of hypermutability in the evolution of the genus Oenococcus.

Authors:  Angela M Marcobal; David A Sela; Yuri I Wolf; Kira S Makarova; David A Mills
Journal:  J Bacteriol       Date:  2007-11-09       Impact factor: 3.490

9.  Distinct roles for the Saccharomyces cerevisiae mismatch repair proteins in heteroduplex rejection, mismatch repair and nonhomologous tail removal.

Authors:  Tamara Goldfarb; Eric Alani
Journal:  Genetics       Date:  2004-10-16       Impact factor: 4.562

10.  UvrD303, a hyperhelicase mutant that antagonizes RecA-dependent SOS expression by a mechanism that depends on its C terminus.

Authors:  Richard C Centore; Michael C Leeson; Steven J Sandler
Journal:  J Bacteriol       Date:  2008-12-12       Impact factor: 3.490
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