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Literature DB >> 16159243

Phenyl radicals react with dinucleoside phosphates by addition to purine bases and H-atom abstraction from a sugar moiety.

Ji-ang Liu¹, Christopher J Petzold, Luis E Ramirez-Arizmendi, James Perez, Hilkka Kenttämaa.

Abstract

Laser-induced acoustic desorption combined with mass spectrometry has been used to demonstrate that phenyl radicals can attack dinucleoside phosphates at both the sugar and base moieties, that purine bases are more susceptible to the attack than pyrimidine bases, and that the more electrophilic the radical, the more efficient the damage to dinucleoside phosphates.

Entities: Chemical

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Year: 2005 PMID： 16159243 DOI： 10.1021/ja052766a

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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Cited

10 in total

1. Direct comparison of solution and gas-phase reactions of the three distonic isomers of the pyridine radical cation with methanol.

Authors: Fanny Widjaja; Zhicheng Jin; John J Nash; Hilkka I Kenttämaa
Journal: J Am Chem Soc Date: 2012-01-18 Impact factor: 15.419

2. Experimental investigations of the internal energy of molecules evaporated via laser-induced acoustic desorption into a Fourier transform ion cyclotron resonance mass spectrometer.

Authors: Ryan C Shea; Christopher J Petzold; Ji-Ang Liu; Hilkka I Kenttämaa
Journal: Anal Chem Date: 2007-01-31 Impact factor: 6.986

3. Reactivity of aromatic sigma, sigma-biradicals toward riboses.

Authors: Anthony Adeuya; Linan Yang; F Sedinam Amegayibor; John J Nash; Hilkka I Kenttämaa
Journal: J Am Soc Mass Spectrom Date: 2006-08-28 Impact factor: 3.109

4. Studies on the mechanism of action of prekinamycin, a member of the diazoparaquinone family of natural products: evidence for both sp2 radical and orthoquinonemethide intermediates.

Authors: Ken S Feldman; Kyle J Eastman
Journal: J Am Chem Soc Date: 2006-09-27 Impact factor: 15.419

5. Reactions of an aromatic σ,σ-biradical with amino acids and dipeptides in the gas phase.

Authors: Mingkun Fu; Sen Li; Enada Archibold; Michael J Yurkovich; John J Nash; Hilkka I Kenttämaa
Journal: J Am Soc Mass Spectrom Date: 2010-06-25 Impact factor: 3.109

6. Design and characterization of a high-power laser-induced acoustic desorption probe coupled with a fourier transform ion cyclotron resonance mass spectrometer.

Authors: Ryan C Shea; Steven C Habicht; Weldon E Vaughn; Hilkka I Kenttämaa
Journal: Anal Chem Date: 2007-02-24 Impact factor: 6.986

Phenyl radicals react with dinucleoside phosphates by addition to purine bases and H-atom abstraction from a sugar moiety.

1. Direct comparison of solution and gas-phase reactions of the three distonic isomers of the pyridine radical cation with methanol.

2. Experimental investigations of the internal energy of molecules evaporated via laser-induced acoustic desorption into a Fourier transform ion cyclotron resonance mass spectrometer.

3. Reactivity of aromatic sigma, sigma-biradicals toward riboses.

4. Studies on the mechanism of action of prekinamycin, a member of the diazoparaquinone family of natural products: evidence for both sp2 radical and orthoquinonemethide intermediates.

5. Reactions of an aromatic σ,σ-biradical with amino acids and dipeptides in the gas phase.

6. Design and characterization of a high-power laser-induced acoustic desorption probe coupled with a fourier transform ion cyclotron resonance mass spectrometer.

7. Gas-phase Reactivity of meta-Benzyne Analogs Toward Small Oligonucleotides of Differing Lengths.

8. Laser-induced acoustic desorption coupled with a linear quadrupole ion trap mass spectrometer.

Review 9. Properties and reactivity of gaseous distonic radical ions with aryl radical sites.

10. Generation and characterization of a distonic biradical anion formed from an enediynone prodrug in the gas phase.