Literature DB >> 16157425

Elicitation of efficient, protective immune responses by using DNA vaccines against tuberculosis.

Aparna Khera1, Ramandeep Singh, H Shakila, Vivek Rao, Neeraj Dhar, P R Narayanan, C N Parmasivan, V D Ramanathan, Anil K Tyagi.   

Abstract

DNA vaccination is an effective method for elicitation of strong humoral as well as cellular immune responses. DNA vaccines expressing mycobacterial antigens ESAT-6 (Rv3875), alpha-crystallin (Rv2031c) and superoxide dismutase A (Rv3846) were evaluated for their immune responses in Balb/c mice and protective efficacy in guinea pigs. Immunization of mice with the DNA vaccines expressing superoxide dismutase A and alpha-crystallin resulted in markedly higher levels of IFN-gamma as compared to the levels of IL-10. The DNA vaccine expressing ESAT-6 elicited a mixed Th1/Th2 response. Immunization of guinea pigs with these DNA vaccines and subsequent challenge of animals with Mycobacterium tuberculosis H(37)Rv, showed that DNA vaccine expressing superoxide dismutase imparted the maximum protection as observed by a 50 and 10 folds reduction in bacillary load in spleens and lungs, respectively, in comparison to immunization with vector control.

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Year:  2005        PMID： 16157425     DOI： 10.1016/j.vaccine.2005.03.056

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  11 in total

1.  Prime-boost vaccination strategy with bacillus Calmette-Guérin (BCG) and liposomized alpha-crystalline protein 1 reinvigorates BCG potency.

Authors:  K F Siddiqui; M Amir; N Khan; G Rama Krishna; J A Sheikh; K Rajagopal; J N Agrewala
Journal:  Clin Exp Immunol       Date:  2015-06-03       Impact factor: 4.330

2.  Multivalent TB vaccines targeting the esx gene family generate potent and broad cell-mediated immune responses superior to BCG.

Authors:  Daniel O Villarreal; Jewell Walters; Dominick J Laddy; Jian Yan; David B Weiner
Journal:  Hum Vaccin Immunother       Date:  2014       Impact factor: 3.452

3.  Acetylome analysis reveals diverse functions of lysine acetylation in Mycobacterium tuberculosis.

Authors:  Fengying Liu; Mingkun Yang; Xude Wang; Shanshan Yang; Jing Gu; Jie Zhou; Xian-En Zhang; Jiaoyu Deng; Feng Ge
Journal:  Mol Cell Proteomics       Date:  2014-09-01       Impact factor: 5.911

4.  Immunoproteomic identification of human T cell antigens of Mycobacterium tuberculosis that differentiate healthy contacts from tuberculosis patients.

Authors:  Anbarasu Deenadayalan; Darragh Heaslip; Adhilakshmi Aavudaiyappan Rajendiran; Banurekha Vaithilingam Velayudham; Sheela Frederick; Hong-Liang Yang; Karen Dobos; John T Belisle; Alamelu Raja
Journal:  Mol Cell Proteomics       Date:  2009-12-22       Impact factor: 5.911

5.  Latency antigen α-crystallin based vaccination imparts a robust protection against TB by modulating the dynamics of pulmonary cytokines.

Authors:  Bappaditya Dey; Ruchi Jain; Aparna Khera; Umesh D Gupta; V M Katoch; V D Ramanathan; Anil K Tyagi
Journal:  PLoS One       Date:  2011-04-18       Impact factor: 3.240

6.  A booster vaccine expressing a latency-associated antigen augments BCG induced immunity and confers enhanced protection against tuberculosis.

Authors:  Bappaditya Dey; Ruchi Jain; Umesh D Gupta; V M Katoch; V D Ramanathan; Anil K Tyagi
Journal:  PLoS One       Date:  2011-08-17       Impact factor: 3.240

7.  Boosting with recombinant MVA expressing M. tuberculosis α-crystallin antigen augments the protection imparted by BCG against tuberculosis in guinea pigs.

Authors:  Prachi Nangpal; Ritika Kar Bahal; Anil K Tyagi
Journal:  Sci Rep       Date:  2017-12-11       Impact factor: 4.379

8.  Adjunctive immunotherapy with α-crystallin based DNA vaccination reduces Tuberculosis chemotherapy period in chronically infected mice.

Authors:  Priyanka Chauhan; Ruchi Jain; Bappaditya Dey; Anil K Tyagi
Journal:  Sci Rep       Date:  2013       Impact factor: 4.379

9.  Proteomic analysis of purified protein derivative of Mycobacterium tuberculosis.

Authors:  Thottethodi Subrahmanya Keshava Prasad; Renu Verma; Satish Kumar; Raja Sekhar Nirujogi; Gajanan J Sathe; Anil K Madugundu; Jyoti Sharma; Vinuth N Puttamallesh; Anjali Ganjiwale; Vithal P Myneedu; Aditi Chatterjee; Akhilesh Pandey; Hc Harsha; Jayasuryan Narayana
Journal:  Clin Proteomics       Date:  2013-07-19       Impact factor: 3.988

10.  Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses.

Authors:  Anat Zvi; Naomi Ariel; John Fulkerson; Jerald C Sadoff; Avigdor Shafferman
Journal:  BMC Med Genomics       Date:  2008-05-28       Impact factor: 3.063
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