Literature DB >> 16154320

The epigenetics of oral cancer.

R Shaw1.   

Abstract

Whilst genetic alterations in oral cancer have long been documented, the appreciation of epigenetic changes is more recent. Epigenetic changes alter expression of tumour suppressor genes without changes in DNA sequence. Epigenetic mechanisms such as DNA methylation, histone methylation and deacetylation have been shown to silence key genes involved in cell proliferation, differentiation and genome integrity, and clearly have a central role in oral cancer. The pattern of hypermethylation in any individual tumour can now be accurately determined, which may find application in molecular staging. In addition, current trials are evaluating the safety and efficacy of agents affecting epigenetic changes in cancer patients which hold some therapeutic promise.

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Year:  2005        PMID： 16154320     DOI： 10.1016/j.ijom.2005.06.014

Source DB:  PubMed          Journal:  Int J Oral Maxillofac Surg        ISSN： 0901-5027            Impact factor:   2.789


  38 in total

1.  miR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients.

Authors:  Gordana Supic; Katarina Zeljic; Aleksandra Divac Rankov; Ruzica Kozomara; Aleksandra Nikolic; Dragica Radojkovic; Zvonko Magic
Journal:  Clin Oral Investig       Date:  2017-06-14       Impact factor: 3.573

2.  An in vitro multistep carcinogenesis model for both HPV-positive and -negative human oral squamous cell carcinomas.

Authors:  Yusuke Zushi; Mako Narisawa-Saito; Kazuma Noguchi; Yuki Yoshimatsu; Takashi Yugawa; Nagayasu Egawa; Masatoshi Fujita; Masahiro Urade; Tohru Kiyono
Journal:  Am J Cancer Res       Date:  2011-08-18       Impact factor: 6.166

3.  Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells.

Authors:  Jacqueline A Gasche; Jürgen Hoffmann; C Richard Boland; Ajay Goel
Journal:  Int J Cancer       Date:  2011-01-07       Impact factor: 7.396

4.  DNA methyltransferase expression in odontogenic cysts and tumours.

Authors:  Carolina Cavaliéri Gomes; João Artur Ricieri Brito; Carlos Inácio Andrade; Ricardo Santiago Gomez
Journal:  Oncol Lett       Date:  2010-01-01       Impact factor: 2.967

5.  Promoter hypermethylation using 24-gene array in early head and neck cancer: better outcome in oral than in oropharyngeal cancer.

Authors:  Rob Noorlag; Pauline M W van Kempen; Cathy B Moelans; Rick de Jong; Laura E R Blok; Ronald Koole; Wilko Grolman; Paul J van Diest; Robert J J van Es; Stefan M Willems
Journal:  Epigenetics       Date:  2014-07-08       Impact factor: 4.528

6.  Genome-wide methylation and expression differences in HPV(+) and HPV(-) squamous cell carcinoma cell lines are consistent with divergent mechanisms of carcinogenesis.

Authors:  Maureen A Sartor; Dana C Dolinoy; Tamara R Jones; Justin A Colacino; Mark E P Prince; Thomas E Carey; Laura S Rozek
Journal:  Epigenetics       Date:  2011-06-01       Impact factor: 4.528

7.  Epigenetic silencing of CRABP2 and MX1 in head and neck tumors.

Authors:  Marilia F Calmon; Rodrigo V Rodrigues; Carla M Kaneto; Ricardo P Moura; Sabrina D Silva; Louise Danielle C Mota; Daniel G Pinheiro; Cesar Torres; Alex F de Carvalho; Patrícia M Cury; Fabio D Nunes; Ines Nobuko Nishimoto; Fernando A Soares; Adriana M A da Silva; Luis P Kowalski; Helena Brentani; Cleslei F Zanelli; Wilson A Silva; Paula Rahal; Eloiza H Tajara; Dirce M Carraro; Anamaria A Camargo; Sandro R Valentini
Journal:  Neoplasia       Date:  2009-12       Impact factor: 5.715

8.  A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.

Authors:  Xiao-Han Tang; Martin Albert; Theresa Scognamiglio; Lorraine J Gudas
Journal:  Cancer Prev Res (Phila)       Date:  2009-12-01

Review 9.  Epigenetics and periodontal disease: future perspectives.

Authors:  Ricardo Santiago Gomez; Walderez Ornelas Dutra; Paula Rocha Moreira
Journal:  Inflamm Res       Date:  2009-05-08       Impact factor: 4.575

10.  Tumor-suppressor Gene Promoter Hypermethylation in Saliva of Head and Neck Cancer Patients.

Authors:  Dmitry A Ovchinnikov; Matthew A Cooper; Pratibala Pandit; William B Coman; Justin J Cooper-White; Patricia Keith; Ernst J Wolvetang; Paul D Slowey; Chamindie Punyadeera
Journal:  Transl Oncol       Date:  2012-10-01       Impact factor: 4.243
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