Literature DB >> 16153851

C3'-cis-Substituted carboxycyclopropyl glycines as metabotropic glutamate 2/3 receptor agonists: synthesis and SAR studies.

Rosario González1, Iván Collado, Beatriz López de Uralde, Alicia Marcos, Luisa M Martín-Cabrejas, Concepción Pedregal, Jaime Blanco-Urgoiti, Javier Pérez-Castells, M Alejandro Fernández, Sherri L Andis, Bryan G Johnson, Rebecca A Wright, Darryle D Schoepp, James A Monn.   

Abstract

The synthesis of a series of C3'-cis-substituted carboxycyclopropyl glycines bearing a wide variety of functional groups is described, and the structure-activity relationship for this series as agonists of group II metabotropic glutamate receptors is reported.

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Year:  2005        PMID: 16153851     DOI: 10.1016/j.bmc.2005.07.036

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN: 0968-0896            Impact factor:   3.641


  1 in total

1.  Design and synthesis of constrained bicyclic molecules as candidate inhibitors of influenza A neuraminidase.

Authors:  Cinzia Colombo; Črtomir Podlipnik; Leonardo Lo Presti; Masahiro Niikura; Andrew J Bennet; Anna Bernardi
Journal:  PLoS One       Date:  2018-02-28       Impact factor: 3.240

  1 in total

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