Literature DB >> 16153594

Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes.

Y Fujii-Kuriyama1, J Mimura.   

Abstract

AhR, a ligand-activated transcription factor, mediates xenobiotic signaling to enhance the expression of target genes, including drug-metabolizing cytochrome P450s. The recent development of several new techniques, including chromatin immunoprecipitation and RNA interference, has expanded and deepened our knowledge of AhR function in the xenobiotic signal transduction. In this review, we briefly summarize our current understanding of the activation and inactivation of AhR activities and discuss the future directions of AhR research.

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Year:  2005        PMID： 16153594     DOI： 10.1016/j.bbrc.2005.08.162

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  73 in total

Review 1.  The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases.

Authors:  Fanny L Casado; Kameshwar P Singh; Thomas A Gasiewicz
Journal:  Blood Cells Mol Dis       Date:  2010-02-19       Impact factor: 3.039

2.  Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events.

Authors:  Heike C Hawerkamp; Andreas Kislat; Peter A Gerber; Marius Pollet; Katharina M Rolfes; Anatoly A Soshilov; Michael S Denison; Afaque A Momin; Stefan T Arold; Angeliki Datsi; Stephan A Braun; Péter Oláh; Mario E Lacouture; Jean Krutmann; Thomas Haarmann-Stemmann; Bernhard Homey; Stephan Meller
Journal:  Allergy       Date:  2019-09-03       Impact factor: 13.146

3.  Overexpression of antioxidant enzymes upregulates aryl hydrocarbon receptor expression via increased Sp1 DNA-binding activity.

Authors:  Tian Tang; Xinghua Lin; Hong Yang; Lichun Zhou; Zefen Wang; Guang Shan; Zhongmao Guo
Journal:  Free Radic Biol Med       Date:  2010-05-15       Impact factor: 7.376

4.  Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells.

Authors:  Zefen Wang; Hong Yang; Aramandla Ramesh; L Jackson Roberts; Lichun Zhou; Xinhua Lin; Yanfeng Zhao; Zhongmao Guo
Journal:  Free Radic Biol Med       Date:  2009-08-07       Impact factor: 7.376

5.  Protective effect of ellagic acid against TCDD-induced renal oxidative stress: modulation of CYP1A1 activity and antioxidant defense mechanisms.

Authors:  Viswanadha Vijaya Padma; Palaniswamy Kalai Selvi; Samadi Sravani
Journal:  Mol Biol Rep       Date:  2014-02-25       Impact factor: 2.316

6.  Novel cellular targets of AhR underlie alterations in neutrophilic inflammation and inducible nitric oxide synthase expression during influenza virus infection.

Authors:  Jennifer L Head Wheeler; Kyle C Martin; B Paige Lawrence
Journal:  J Immunol       Date:  2012-12-10       Impact factor: 5.422

Review 7.  The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells.

Authors:  Eszter Baricza; Viola Tamási; Nikolett Marton; Edit I Buzás; György Nagy
Journal:  Cell Mol Life Sci       Date:  2015-10-28       Impact factor: 9.261

8.  Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters.

Authors:  Weiwu Jiang; Lihua Wang; Weisheng Zhang; Richard Coffee; Inayat S Fazili; Bhagavatula Moorthy
Journal:  Biochem Biophys Res Commun       Date:  2009-11-11       Impact factor: 3.575

9.  Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter.

Authors:  Inayat S Fazili; Weiwu Jiang; Lihua Wang; Edward A Felix; Tanvir Khatlani; Xavier Coumoul; Robert Barouki; Bhagavatula Moorthy
Journal:  J Pharmacol Exp Ther       Date:  2010-01-05       Impact factor: 4.030

Review 10.  Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention.

Authors:  Vasilis P Androutsopoulos; Aristidis M Tsatsakis; Demetrios A Spandidos
Journal:  BMC Cancer       Date:  2009-06-16       Impact factor: 4.430
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