OBJECTIVES: Approximately 40% of patients with Parkinson's disease (PD) experience symptoms of depression. Our aim was to evaluate the effect of depression on disease severity, motor function and other phenotypic characteristics of PD. PATIENTS AND METHODS: We studied 32 PD patients with major depression (PD-D) according to the DSM-IV criteria and 32 PD patients with no depression (PD-C) matched for gender, age of onset and duration. RESULTS: Major depression in PD patients was associated with increased disease severity, poorer motor function and worse performance in the activities of daily living as measured by UPDRS scores. Furthermore, there was an association of depression with the severity of bradykinesia and axial rigidity. CONCLUSIONS: Depression in PD can have a profound negative impact on a patient's sense of wellbeing and motor functioning. Therefore, PD patients should be routinely and carefully screened for the presence of depression and appropriate management should be considered. Larger studies on the subject are warranted.
OBJECTIVES: Approximately 40% of patients with Parkinson's disease (PD) experience symptoms of depression. Our aim was to evaluate the effect of depression on disease severity, motor function and other phenotypic characteristics of PD. PATIENTS AND METHODS: We studied 32 PDpatients with major depression (PD-D) according to the DSM-IV criteria and 32 PDpatients with no depression (PD-C) matched for gender, age of onset and duration. RESULTS:Major depression in PDpatients was associated with increased disease severity, poorer motor function and worse performance in the activities of daily living as measured by UPDRS scores. Furthermore, there was an association of depression with the severity of bradykinesia and axial rigidity. CONCLUSIONS:Depression in PD can have a profound negative impact on a patient's sense of wellbeing and motor functioning. Therefore, PDpatients should be routinely and carefully screened for the presence of depression and appropriate management should be considered. Larger studies on the subject are warranted.
Authors: Daniel A Nation; Heather L Katzen; Spyridon Papapetropoulos; Blake K Scanlon; Bonnie E Levin Journal: Int J Geriatr Psychiatry Date: 2009-09 Impact factor: 3.485
Authors: Andreas Horn; Martin Reich; Johannes Vorwerk; Ningfei Li; Gregor Wenzel; Qianqian Fang; Tanja Schmitz-Hübsch; Robert Nickl; Andreas Kupsch; Jens Volkmann; Andrea A Kühn; Michael D Fox Journal: Ann Neurol Date: 2017-07 Impact factor: 10.422
Authors: Priya V Mhatre; Iris Vilares; Stacy M Stibb; Mark V Albert; Laura Pickering; Christina M Marciniak; Konrad Kording; Santiago Toledo Journal: PM R Date: 2013-06-11 Impact factor: 2.298