Literature DB >> 16146359

Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export.

Savvas N Georgiades1, Jon Clardy.   

Abstract

[reaction: see text] Two inhibitors of FOXO1a-mediated nuclear export, psammaplysenes A and B, have been synthesized by a flexible and efficient route. A common starting material, 4-iodophenol, was used to prepare both halves of these pseudosymmetric dibromotyrosine-derived metabolites.

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Year:  2005        PMID： 16146359     DOI： 10.1021/ol0513286

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  10 in total

1.  Preparation of a psammaplysene-based library.

Authors:  Savvas N Georgiades; Jon Clardy
Journal:  Org Lett       Date:  2006-09-14       Impact factor: 6.005

2.  Induction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1.

Authors:  Emily Berry; Jennifer L Hardt; Jon Clardy; John R Lurain; J Julie Kim
Journal:  Gynecol Oncol       Date:  2008-11-28       Impact factor: 5.482

3.  FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases.

Authors:  Jelena Mojsilovic-Petrovic; Natalia Nedelsky; Marco Boccitto; Itzhak Mano; Savvas N Georgiades; Weiguo Zhou; Yuhong Liu; Rachael L Neve; J Paul Taylor; Monica Driscoll; Jon Clardy; Diane Merry; Robert G Kalb
Journal:  J Neurosci       Date:  2009-06-24       Impact factor: 6.167

4.  A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A.

Authors:  Jingjing Xu; Kai Wang; Jinlong Wu
Journal:  RSC Adv       Date:  2018-04-12       Impact factor: 4.036

5.  Progestins activate the AKT pathway in leiomyoma cells and promote survival.

Authors:  Anna V Hoekstra; Elizabeth C Sefton; Emily Berry; Zhenxiao Lu; Jennifer Hardt; Erica Marsh; Ping Yin; Jon Clardy; Debabrata Chakravarti; Serdar Bulun; J Julie Kim
Journal:  J Clin Endocrinol Metab       Date:  2009-02-24       Impact factor: 5.958

Review 6.  Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment.

Authors:  Magbubah Essack; Vladimir B Bajic; John A C Archer
Journal:  Mar Drugs       Date:  2011-09-20       Impact factor: 6.085

7.  The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK.

Authors:  Marco Boccitto; Nayoung Lee; Satoshi Sakamoto; Lynn A Spruce; Hiroshi Handa; Jon Clardy; Steven H Seeholzer; Robert G Kalb
Journal:  Mar Drugs       Date:  2017-08-07       Impact factor: 5.118

8.  Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis.

Authors:  Amr El-Demerdash; Céline Moriou; Jordan Toullec; Marc Besson; Stéphanie Soulet; Nelly Schmitt; Sylvain Petek; David Lecchini; Cécile Debitus; Ali Al-Mourabit
Journal:  Mar Drugs       Date:  2018-04-27       Impact factor: 5.118

9.  Towards the small and the beautiful: a small dibromotyrosine derivative from Pseudoceratina sp. sponge exhibits potent apoptotic effect through targeting IKK/NFκB signaling pathway.

Authors:  Jui-Hsin Su; Yu-Cheng Chen; Mohamed El-Shazly; Ying-Chi Du; Chiang-Wen Su; Chia-Wei Tsao; Li-Lian Liu; Yalan Chou; Wen-Been Chang; Yin-Di Su; Michael Y Chiang; Yao-Tsung Yeh; Mei-Chin Lu
Journal:  Mar Drugs       Date:  2013-08-26       Impact factor: 5.118

Review 10.  Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem".

Authors:  Nelson G M Gomes; Ramesh Dasari; Sunena Chandra; Robert Kiss; Alexander Kornienko
Journal:  Mar Drugs       Date:  2016-05-21       Impact factor: 5.118
  10 in total

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