Literature DB >> 16144372

Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates.

Peter Wipf1, Jingbo Xiao, Jianfei Jiang, Natalia A Belikova, Vladimir A Tyurin, Mitchell P Fink, Valerian E Kagan.   

Abstract

Synthetic hemigramicidin S-peptidyl TEMPO conjugates are effectively delivered into cells and mitochondria, where they act as electron scavengers and exert protection against apoptosis. Our delivery approach is based on the use of specific structural signaling features recognizable by cells as mitochondria targeting sequences and offers considerable therapeutic anti-apoptotic potential.

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Year:  2005        PMID： 16144372     DOI： 10.1021/ja053679l

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  65 in total

1.  Peptide-Like Molecules (PLMs): A Journey from Peptide Bond Isosteres to Gramicidin S Mimetics and Mitochondrial Targeting Agents.

Authors:  Peter Wipf; Jingbo Xiao; Corey R J Stephenson
Journal:  Chimia (Aarau)       Date:  2009-11       Impact factor: 1.509

Review 2.  A review of the effects of FSCV and microdialysis measurements on dopamine release in the surrounding tissue.

Authors:  Andrea Jaquins-Gerstl; Adrian C Michael
Journal:  Analyst       Date:  2015-06-07       Impact factor: 4.616

Review 3.  Mitochondria as a target in treatment.

Authors:  Marie-Céline Frantz; Peter Wipf
Journal:  Environ Mol Mutagen       Date:  2010-06       Impact factor: 3.216

4.  Mitochondrial targeting of radioprotectants using peptidyl conjugates.

Authors:  Anthony Kanai; Irina Zabbarova; Andrew Amoscato; Michael Epperly; Jingbo Xiao; Peter Wipf
Journal:  Org Biomol Chem       Date:  2006-12-07       Impact factor: 3.876

5.  Molecular design of new inhibitors of peroxidase activity of cytochrome c/cardiolipin complexes: fluorescent oxadiazole-derivatized cardiolipin.

Authors:  G G Borisenko; A A Kapralov; V A Tyurin; A Maeda; D A Stoyanovsky; V E Kagan
Journal:  Biochemistry       Date:  2008-12-23       Impact factor: 3.162

6.  Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis.

Authors:  Zhaohui Liu; Alicia M Celotto; Guillermo Romero; Peter Wipf; Michael J Palladino
Journal:  Neurobiol Dis       Date:  2011-08-25       Impact factor: 5.996

7.  Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration.

Authors:  Luigi A Nasto; Andria R Robinson; Kevin Ngo; Cheryl L Clauson; Qing Dong; Claudette St Croix; Gwendolyn Sowa; Enrico Pola; Paul D Robbins; James Kang; Laura J Niedernhofer; Peter Wipf; Nam V Vo
Journal:  J Orthop Res       Date:  2013-02-06       Impact factor: 3.494

8.  Development of spin-labeled pargyline analogues as specific inhibitors of human monoamine oxidases A and B.

Authors:  Anup K Upadhyay; Dale E Edmondson
Journal:  Biochemistry       Date:  2009-05-12       Impact factor: 3.162

Review 9.  Targeted delivery of radioprotective agents to mitochondria.

Authors:  Irina Zabbarova; Anthony Kanai
Journal:  Mol Interv       Date:  2008-12

10.  The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair.

Authors:  Malolan S Rajagopalan; Kanika Gupta; Michael W Epperly; Darcy Franicola; Xichen Zhang; Hong Wang; Hong Zhao; Vladimir A Tyurin; Joshua G Pierce; Valerian E Kagan; Peter Wipf; Anthony J Kanai; Joel S Greenberger
Journal:  In Vivo       Date:  2009 Sep-Oct       Impact factor: 2.155
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