| Literature DB >> 16143532 |
Johann Leban1, Martin Kralik, Jan Mies, Michael Gassen, Karin Tentschert, Roland Baumgartner.
Abstract
Novel DHODH inhibitors were developed based on a previously described series by introduction of heteroatoms into the cyclopentene ring and hydroxyl groups attached to it. Also, the hydrophobic biphenyl side chain was replaced with benzyloxy phenyl groups. Activities on human, rat, and mouse enzymes indicate a species specificity of these inhibitors.Entities:
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Year: 2005 PMID： 16143532 DOI： 10.1016/j.bmcl.2005.07.053
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823