Literature DB >> 16140789

Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.

Robert Thimme1, Victor Appay, Marie Koschella, Elisabeth Panther, Evelyn Roth, Andrew D Hislop, Alan B Rickinson, Sarah L Rowland-Jones, Hubert E Blum, Hanspeter Pircher.   

Abstract

The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells in mice and that virus-specific CD8+ T cells are mostly KLRG1+ in chronic human viral infections (human immunodeficiency virus, cytomegalovirus, and Epstein-Barr virus) but not in resolved infection (influenza virus). Thus, by using KLRG1 as a T-cell marker, our results suggest that the differentiation status and function of virus-specific CD8+ T cells are directly influenced by persistent antigen stimulation.

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Year:  2005        PMID： 16140789      PMCID： PMC1212638          DOI： 10.1128/JVI.79.18.12112-12116.2005

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  35 in total

1.  Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.

Authors:  F Sallusto; D Lenig; R Förster; M Lipp; A Lanzavecchia
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2.  Cutting edge: naive T cells masquerading as memory cells.

Authors:  K Murali-Krishna; R Ahmed
Journal:  J Immunol       Date:  2000-08-15       Impact factor: 5.422

3.  Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7.

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Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

4.  2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells.

Authors:  T Hanke; L Corral; R E Vance; D H Raulet
Journal:  Eur J Immunol       Date:  1998-12       Impact factor: 5.532

5.  Virus-activated CD8 T cells and lymphokine-activated NK cells express the mast cell function-associated antigen, an inhibitory C-type lectin.

Authors:  C Blaser; M Kaufmann; H Pircher
Journal:  J Immunol       Date:  1998-12-15       Impact factor: 5.422

6.  Differential expression of leukocyte receptor complex-encoded Ig-like receptors correlates with the transition from effector to memory CTL.

Authors:  N T Young; M Uhrberg; J H Phillips; L L Lanier; P Parham
Journal:  J Immunol       Date:  2001-03-15       Impact factor: 5.422

7.  NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules.

Authors:  L Corral; T Hanke; R E Vance; D Cado; D H Raulet
Journal:  Eur J Immunol       Date:  2000-03       Impact factor: 5.532

8.  Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1).

Authors:  Matthias Eberl; Rosel Engel; Silke Aberle; Paul Fisch; Hassan Jomaa; Hanspeter Pircher
Journal:  J Leukoc Biol       Date:  2004-10-21       Impact factor: 4.962

9.  CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus.

Authors:  A R Thomsen; A Nansen; J P Christensen; S O Andreasen; O Marker
Journal:  J Immunol       Date:  1998-11-01       Impact factor: 5.422

10.  CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection.

Authors:  P Borrow; D F Tough; D Eto; A Tishon; I S Grewal; J Sprent; R A Flavell; M B Oldstone
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103
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  72 in total

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Authors:  Sian M Henson; Arne N Akbar
Journal:  Age (Dordr)       Date:  2009-12

2.  Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells.

Authors:  Tihana Tršan; Kristina Vuković; Petra Filipović; Ana Lesac Brizić; Niels A W Lemmermann; Kilian Schober; Dirk H Busch; William J Britt; Martin Messerle; Astrid Krmpotić; Stipan Jonjić
Journal:  Eur J Immunol       Date:  2017-07-04       Impact factor: 5.532

3.  Early KLRG1+ but Not CD57+CD8+ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control.

Authors:  Aki Hoji; Iulia D Popescu; Matthew R Pipeling; Pali D Shah; Spencer A Winters; John F McDyer
Journal:  J Immunol       Date:  2019-09-25       Impact factor: 5.422

4.  Antigen display, T-cell activation, and immune evasion during acute and chronic ehrlichiosis.

Authors:  Bisweswar Nandi; Madhumouli Chatterjee; Kathryn Hogle; Maura McLaughlin; Katherine MacNamara; Rachael Racine; Gary M Winslow
Journal:  Infect Immun       Date:  2009-07-27       Impact factor: 3.441

5.  Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition.

Authors:  Yili Li; Maike Hofmann; Qian Wang; Leslie Teng; Lukasz K Chlewicki; Hanspeter Pircher; Roy A Mariuzza
Journal:  Immunity       Date:  2009-07-17       Impact factor: 31.745

6.  Persistence of transgene expression influences CD8+ T-cell expansion and maintenance following immunization with recombinant adenovirus.

Authors:  Jonathan D Finn; Jennifer Bassett; James B Millar; Natalie Grinshtein; Teng Chih Yang; Robin Parsons; Carole Evelegh; Yonghong Wan; Robin J Parks; Jonathan L Bramson
Journal:  J Virol       Date:  2009-09-16       Impact factor: 5.103

7.  Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells.

Authors:  Wenting Huang; Kritika Kachapati; David Adams; Yuehong Wu; Patrick S C Leung; Guo-Xiang Yang; Weici Zhang; Aftab A Ansari; Richard A Flavell; M Eric Gershwin; William M Ridgway
Journal:  J Autoimmun       Date:  2014-02-18       Impact factor: 7.094

8.  Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells.

Authors:  Christopher M Snyder; Kathy S Cho; Elizabeth L Bonnett; Serani van Dommelen; Geoffrey R Shellam; Ann B Hill
Journal:  Immunity       Date:  2008-10-17       Impact factor: 31.745

9.  Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver.

Authors:  Bertram Bengsch; Hans Christian Spangenberg; Nadine Kersting; Christoph Neumann-Haefelin; Elisabeth Panther; Fritz von Weizsäcker; Hubert E Blum; Hanspeter Pircher; Robert Thimme
Journal:  J Virol       Date:  2006-11-01       Impact factor: 5.103

10.  Two kinetic patterns of epitope-specific CD8 T-cell responses following murine gammaherpesvirus 68 infection.

Authors:  Michael L Freeman; Kathleen G Lanzer; Tres Cookenham; Bjoern Peters; John Sidney; Ting-Ting Wu; Ren Sun; David L Woodland; Alessandro Sette; Marcia A Blackman
Journal:  J Virol       Date:  2010-01-06       Impact factor: 5.103
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