Literature DB >> 19479342

KLRG1--more than a marker for T cell senescence.

Sian M Henson1, Arne N Akbar.   

Abstract

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells and antigen-experienced T cells and has been postulated to be a marker of senescence. Whilst KLRG1 has frequently been used as a marker of cellular differentiation, data are emerging indicating that KLRG1 plays an inhibitory role. In this review we examine evidence highlighting this view of KLRG1 with emphasis on the functional defects that arise during T cell differentiation with age that may, in part, be actively maintained by inhibitory receptor signalling.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19479342      PMCID： PMC2813054          DOI： 10.1007/s11357-009-9100-9

Source DB:  PubMed          Journal:  Age (Dordr)        ISSN： 0161-9152


  59 in total

1.  KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells.

Authors:  Sian M Henson; Ornella Franzese; Richard Macaulay; Valentina Libri; Rita I Azevedo; Sorena Kiani-Alikhan; Fiona J Plunkett; Joanne E Masters; Sarah Jackson; Stephen J Griffiths; Hans-Peter Pircher; Maria V D Soares; Arne N Akbar
Journal:  Blood       Date:  2009-04-30       Impact factor: 22.113

2.  Cutting edge: inhibitory functions of the killer cell lectin-like receptor G1 molecule during the activation of mouse NK cells.

Authors:  Scott H Robbins; Khuong B Nguyen; Nobuaki Takahashi; Toshifumi Mikayama; Christine A Biron; Laurent Brossay
Journal:  J Immunol       Date:  2002-03-15       Impact factor: 5.422

Review 3.  The role of CD8+ T-cell replicative senescence in human aging.

Authors:  Rita B Effros; Mirabelle Dagarag; Carolyn Spaulding; Janice Man
Journal:  Immunol Rev       Date:  2005-06       Impact factor: 12.988

4.  Mechanism of activation of protein kinase B by insulin and IGF-1.

Authors:  D R Alessi; M Andjelkovic; B Caudwell; P Cron; N Morrice; P Cohen; B A Hemmings
Journal:  EMBO J       Date:  1996-12-02       Impact factor: 11.598

5.  Costimulation of human CD28- T cells by 4-1BB ligand.

Authors:  Jacob Bukczynski; Tao Wen; Tania H Watts
Journal:  Eur J Immunol       Date:  2003-02       Impact factor: 5.532

6.  Bacterial meningitis in the elderly.

Authors:  G J Gorse; L D Thrupp; K L Nudleman; F A Wyle; B Hawkins; T C Cesario
Journal:  Arch Intern Med       Date:  1984-08

7.  Changes in thymic function with age and during the treatment of HIV infection.

Authors:  D C Douek; R D McFarland; P H Keiser; E A Gage; J M Massey; B F Haynes; M A Polis; A T Haase; M B Feinberg; J L Sullivan; B D Jamieson; J A Zack; L J Picker; R A Koup
Journal:  Nature       Date:  1998-12-17       Impact factor: 49.962

8.  Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1).

Authors:  David Voehringer; Marie Koschella; Hanspeter Pircher
Journal:  Blood       Date:  2002-07-12       Impact factor: 22.113

9.  Phenotypic and functional separation of memory and effector human CD8+ T cells.

Authors:  D Hamann; P A Baars; M H Rep; B Hooibrink; S R Kerkhof-Garde; M R Klein; R A van Lier
Journal:  J Exp Med       Date:  1997-11-03       Impact factor: 14.307

10.  Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection.

Authors:  Elisabeth Amyes; Chris Hatton; Damien Montamat-Sicotte; Nancy Gudgeon; Alan B Rickinson; Andrew J McMichael; Margaret F C Callan
Journal:  J Exp Med       Date:  2003-09-15       Impact factor: 14.307
View more
  69 in total

1.  Transplantation preferentially induces a KLRG-1lo CD127hi differentiation program in antigen-specific CD8+ T cells.

Authors:  Alana M Bozeman; Sonia J Laurie; Divya Haridas; Maylene E Wagener; Mandy L Ford
Journal:  Transpl Immunol       Date:  2018-06-08       Impact factor: 1.708

2.  Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection.

Authors:  Joselyn Rojas-Quintero; Xiaoyun Wang; Jennifer Tipper; Patrick R Burkett; Joaquin Zuñiga; Amit R Ashtekar; Francesca Polverino; Amit Rout; Ilyas Yambayev; Carmen Hernández; Luis Jimenez; Gustavo Ramírez; Kevin S Harrod; Caroline A Owen
Journal:  JCI Insight       Date:  2018-12-20

3.  Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

Authors:  Arne N Akbar; Sian M Henson
Journal:  Nat Rev Immunol       Date:  2011-04       Impact factor: 53.106

4.  Lifelong training improves anti-inflammatory environment and maintains the number of regulatory T cells in masters athletes.

Authors:  Luciele G Minuzzi; Luis Rama; Nicolette C Bishop; Fátima Rosado; António Martinho; Artur Paiva; Ana M Teixeira
Journal:  Eur J Appl Physiol       Date:  2017-04-08       Impact factor: 3.078

Review 5.  HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction.

Authors:  Sumati Rajagopalan
Journal:  Cell Mol Immunol       Date:  2014-07-07       Impact factor: 11.530

Review 6.  Environmental cues orchestrate regional immune surveillance and protection by pulmonary CTLs.

Authors:  Linda S Cauley
Journal:  J Leukoc Biol       Date:  2016-06-17       Impact factor: 4.962

7.  Epithelial-mesenchymal transition leads to NK cell-mediated metastasis-specific immunosurveillance in lung cancer.

Authors:  Peter J Chockley; Jun Chen; Guoan Chen; David G Beer; Theodore J Standiford; Venkateshwar G Keshamouni
Journal:  J Clin Invest       Date:  2018-02-26       Impact factor: 14.808

8.  CD83 expression is essential for Treg cell differentiation and stability.

Authors:  Marina Doebbeler; Christina Koenig; Lena Krzyzak; Christine Seitz; Andreas Wild; Thomas Ulas; Kevin Baßler; Dmitry Kopelyanskiy; Alina Butterhof; Christine Kuhnt; Simon Kreiser; Lena Stich; Elisabeth Zinser; Ilka Knippertz; Stefan Wirtz; Christin Riegel; Petra Hoffmann; Matthias Edinger; Lars Nitschke; Thomas Winkler; Joachim L Schultze; Alexander Steinkasserer; Matthias Lechmann
Journal:  JCI Insight       Date:  2018-06-07

Review 9.  Challenges and future perspectives of T cell immunotherapy in cancer.

Authors:  Maria Teresa P de Aquino; Anshu Malhotra; Manoj K Mishra; Anil Shanker
Journal:  Immunol Lett       Date:  2015-06-19       Impact factor: 3.685

10.  Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans.

Authors:  Douglas V Dolfi; Kathleen D Mansfield; Antonio M Polley; Susan A Doyle; Gordon J Freeman; Hanspeter Pircher; Kenneth E Schmader; E John Wherry
Journal:  J Leukoc Biol       Date:  2013-02-25       Impact factor: 4.962
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.