| Literature DB >> 16140015 |
John W van Klink1, Lesley Larsen, Nigel B Perry, Rex T Weavers, Gregory M Cook, Phil J Bremer, Andrew D MacKenzie, Teruo Kirikae.
Abstract
A series of acylated phloroglucinols and triketones was synthesized and tested for activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE) and multi-drug-resistant Mycobacterium tuberculosis (MDR-TB). A tetra-methylated triketone with a C12 side chain was the most active compound (MIC of around 1.0 microg/ml against MRSA) and was shown to stimulate oxygen consumption by resting cell suspensions, suggesting that the primary target was the cytoplasmic membrane.Entities:
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Year: 2005 PMID： 16140015 DOI： 10.1016/j.bmc.2005.07.045
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641