Literature DB >> 16137784

High intrinsic oxidative stress may underlie selective vulnerability of the hippocampal CA1 region.

Xinkun Wang1, Ranu Pal, Xue-Wen Chen, Nanteetip Limpeanchob, Keshava N Kumar, Elias K Michaelis.   

Abstract

Oxidative stress (OS) causes extensive cell death in the CA1 but not the CA3 region of the hippocampus. We found that the CA1 region of hippocampus explants, cultured under normal conditions, had significantly higher superoxide levels and expressed both anti-oxidant genes and genes related to the generation of reactive oxygen species at significantly higher levels than the CA3. These observations were indicative of high intrinsic OS in CA1.

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Year:  2005        PMID： 16137784     DOI： 10.1016/j.molbrainres.2005.07.018

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  38 in total

1.  Genome-wide transcriptome profiling of region-specific vulnerability to oxidative stress in the hippocampus.

Authors:  Xinkun Wang; Ranu Pal; Xue-wen Chen; Keshava N Kumar; Ok-Jin Kim; Elias K Michaelis
Journal:  Genomics       Date:  2007-06-05       Impact factor: 5.736

Review 2.  Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates.

Authors:  Valentina R Garbarino; Miranda E Orr; Karl A Rodriguez; Rochelle Buffenstein
Journal:  Arch Biochem Biophys       Date:  2015-04-01       Impact factor: 4.013

3.  Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain.

Authors:  J Ivanidze; M Mackay; A Hoang; J M Chi; K Cheng; C Aranow; B Volpe; B Diamond; P C Sanelli
Journal:  AJNR Am J Neuroradiol       Date:  2019-02-07       Impact factor: 3.825

4.  Neurological Impairments in Mice Subjected to Irradiation and Chemotherapy.

Authors:  Deblina Dey; Vipan K Parihar; Gergely G Szabo; Peter M Klein; Jenny Tran; Jonathan Moayyad; Faizy Ahmed; Quynh-Anh Nguyen; Alexandria Murry; David Merriott; Brandon Nguyen; Jodi Goldman; Maria C Angulo; Daniele Piomelli; Ivan Soltesz; Janet E Baulch; Charles L Limoli
Journal:  Radiat Res       Date:  2020-03-05       Impact factor: 2.841

5.  Oxidative mitochondrial DNA damage in peripheral blood mononuclear cells is associated with reduced volumes of hippocampus and subcortical gray matter in chronically HIV-infected patients.

Authors:  Kalpana J Kallianpur; Mariana Gerschenson; Brooks I Mitchell; Daniel E LiButti; Tracie M Umaki; Lishomwa C Ndhlovu; Beau K Nakamoto; Dominic C Chow; Cecilia M Shikuma
Journal:  Mitochondrion       Date:  2016-02-23       Impact factor: 4.160

6.  Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.

Authors:  In-Young Choi; Phil Lee; Wen-Tung Wang; Dongwei Hui; Xinkun Wang; William M Brooks; Elias K Michaelis
Journal:  Neurochem Res       Date:  2014-01-21       Impact factor: 3.996

Review 7.  Transient amnesic syndromes.

Authors:  Thorsten Bartsch; Christopher Butler
Journal:  Nat Rev Neurol       Date:  2013-01-08       Impact factor: 42.937

8.  Ischemic tolerance in an in vivo model of glutamate preconditioning.

Authors:  Yomna Badawi; Ranu Pal; Dongwei Hui; Elias K Michaelis; Honglian Shi
Journal:  J Neurosci Res       Date:  2014-11-25       Impact factor: 4.164

9.  Selective neuronal vulnerability to oxidative stress in the brain.

Authors:  Xinkun Wang; Elias K Michaelis
Journal:  Front Aging Neurosci       Date:  2010-03-30       Impact factor: 5.750

10.  Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress.

Authors:  Xinkun Wang; Asma Zaidi; Ranu Pal; Alexander S Garrett; Rogelio Braceras; Xue-wen Chen; Mary L Michaelis; Elias K Michaelis
Journal:  BMC Neurosci       Date:  2009-02-19       Impact factor: 3.288
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