Literature DB >> 30733256

Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain.

J Ivanidze1, M Mackay2,3, A Hoang4,3, J M Chi5,3, K Cheng5,3, C Aranow2,3, B Volpe6,3, B Diamond2,3, P C Sanelli7,4,8,3.   

Abstract

We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role.
© 2019 by American Journal of Neuroradiology.

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Year:  2019        PMID： 30733256      PMCID： PMC7028673          DOI： 10.3174/ajnr.A5962

Source DB:  PubMed          Journal:  AJNR Am J Neuroradiol        ISSN： 0195-6108            Impact factor:   3.825


  19 in total

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3.  Posterior reversible encephalopathy syndrome on computed tomography perfusion in a patient on "Triple H" therapy.

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Review 5.  Working memory, long-term memory, and medial temporal lobe function.

Authors:  Annette Jeneson; Larry R Squire
Journal:  Learn Mem       Date:  2011-12-16       Impact factor: 2.460

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Authors:  P C Sanelli; I Ugorec; C E Johnson; J Tan; A Z Segal; M Fink; L A Heier; A J Tsiouris; J P Comunale; M John; P E Stieg; R D Zimmerman; A I Mushlin
Journal:  AJNR Am J Neuroradiol       Date:  2011-09-29       Impact factor: 3.825

7.  Selective neuronal vulnerability of human hippocampal CA1 neurons: lesion evolution, temporal course, and pattern of hippocampal damage in diffusion-weighted MR imaging.

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Journal:  Neuron       Date:  2015-01-21       Impact factor: 17.173
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  8 in total

1.  Methodologic Concerns on the Reported Values for Assessing Permeability of the Blood-Brain Barrier in the Hippocampus.

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Review 4.  Alcohol, inflammation, and blood-brain barrier function in health and disease across development.

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Journal:  Int Rev Neurobiol       Date:  2021-08-11       Impact factor: 4.280

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Journal:  Semin Cell Dev Biol       Date:  2021-05-12       Impact factor: 7.499

6.  Regional Differences in Blood-Brain Barrier Permeability in Cognitively Normal Elderly Subjects: A Dynamic Contrast-Enhanced MRI-Based Study.

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7.  Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging.

Authors:  Jeremy N Ford; Qihao Zhang; Elizabeth M Sweeney; Alexander E Merkler; Mony J de Leon; Ajay Gupta; Thanh D Nguyen; Jana Ivanidze
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8.  The progression of carotid atherosclerosis and imaging markers of dementia.

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  8 in total

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