UNLABELLED: Senescence and chronic renal failure bring about a progressive glomerular filtration reduction. Moreover, a reduction in glomerular filtration usually modifies the potassium renal excretion. In the present study, we compared the renal potassium handling between old and chronic renal disease populations. MATERIALS AND METHODS: Fifty-five volunteers were studied, 43 of them were healthy old persons and 12 were predialysis chronic renal disease patients. Exclusion criteria were: presence of altered plasma potassium (Kp), diabetes mellitus, obstructive uropathy, drugs that could alter plasma potassium levels. All volunteers were on a diet with a potassium content around 50 mmol/day (3-day dietary register). We measured potassium, creatinine, urea in plasma and 24 hours urine. We also measured creatinine clearance (CrCl) and fractional excretion of potassium (FEK), and we studied the relationship between these parameters. Statistical analysis was made using Student's test. RESULTS: Slopes of the correlation curves between CrCl and FEK. [Table: see text]. CONCLUSION: The relationship between creatinine clearance and fractional excretion of potassium in old and chronic renal disease groups were different with the excretion of potassium being lower in the elderly.
UNLABELLED: Senescence and chronic renal failure bring about a progressive glomerular filtration reduction. Moreover, a reduction in glomerular filtration usually modifies the potassiumrenal excretion. In the present study, we compared the renal potassium handling between old and chronic renal disease populations. MATERIALS AND METHODS: Fifty-five volunteers were studied, 43 of them were healthy old persons and 12 were predialysis chronic renal diseasepatients. Exclusion criteria were: presence of altered plasma potassium (Kp), diabetes mellitus, obstructive uropathy, drugs that could alter plasma potassium levels. All volunteers were on a diet with a potassium content around 50 mmol/day (3-day dietary register). We measured potassium, creatinine, urea in plasma and 24 hours urine. We also measured creatinine clearance (CrCl) and fractional excretion of potassium (FEK), and we studied the relationship between these parameters. Statistical analysis was made using Student's test. RESULTS: Slopes of the correlation curves between CrCl and FEK. [Table: see text]. CONCLUSION: The relationship between creatinine clearance and fractional excretion of potassium in old and chronic renal disease groups were different with the excretion of potassium being lower in the elderly.
Authors: Carlos G Musso; Matilde Navarro; Cesar Mombelli; Cora Giordani; Roxana Groppa; B Martinez; Raul De Miguel; Nora Imperiali Journal: Int Urol Nephrol Date: 2012-12-13 Impact factor: 2.370
Authors: Carlos Guido Musso; Juliana Reynaldi; Manuel Vilas; Raul De Miguel; Nora Imperiali; Luis Algranati Journal: Int Urol Nephrol Date: 2009-03-10 Impact factor: 2.370
Authors: Hong Ji; Wei Zheng; Xie Wu; Robert C Speth; Joseph G Verbalis; Lauren M Stein; Gina L C Yosten; Willis K Samson; Kathryn Sandberg Journal: Am J Physiol Regul Integr Comp Physiol Date: 2015-12-23 Impact factor: 3.619