BACKGROUND: Interleukin 1 (IL-1) is a proinflammatory cytokine involved in atherogenesis and thrombosis. The aim of this study was to investigate the association between the IL-1beta gene polymorphism (-511) and the risk of large vessel disease (LVD) stroke, small vessel disease (SVD) stroke and cardioembolic (CE) stroke. METHODS: We genotyped 115 patients with LVD stroke and 194 matched controls, 122 patients with SVD stroke and 227 controls and 221 patients with CE stroke and 219 controls. The IL-1beta polymorphism was analyzed by a polymerase chain reaction followed by a restriction enzyme digestion. RESULTS: The allele T distribution did not change significantly between patients with LVD stroke and their controls nor between patients with CE stroke and their controls. The frequency of the T allele was higher in patients with SVD stroke than in the control group (37.7 vs. 30.4%, p = 0.05). After adjustment for vascular risk factor, the TT genotype was an independent risk factor for SVD stroke (OR: 2.40, 95% CI: 1.17-4.94). CONCLUSIONS: The TT genotype of the IL-1beta gene may be associated with an increased risk of SVD stroke. Copyright 2005 S. Karger AG, Basel.
BACKGROUND:Interleukin 1 (IL-1) is a proinflammatory cytokine involved in atherogenesis and thrombosis. The aim of this study was to investigate the association between the IL-1beta gene polymorphism (-511) and the risk of large vessel disease (LVD) stroke, small vessel disease (SVD) stroke and cardioembolic (CE) stroke. METHODS: We genotyped 115 patients with LVD stroke and 194 matched controls, 122 patients with SVD stroke and 227 controls and 221 patients with CE stroke and 219 controls. The IL-1beta polymorphism was analyzed by a polymerase chain reaction followed by a restriction enzyme digestion. RESULTS: The allele T distribution did not change significantly between patients with LVD stroke and their controls nor between patients with CE stroke and their controls. The frequency of the T allele was higher in patients with SVD stroke than in the control group (37.7 vs. 30.4%, p = 0.05). After adjustment for vascular risk factor, the TT genotype was an independent risk factor for SVD stroke (OR: 2.40, 95% CI: 1.17-4.94). CONCLUSIONS: The TT genotype of the IL-1beta gene may be associated with an increased risk of SVD stroke. Copyright 2005 S. Karger AG, Basel.
Authors: Inna Belfer; Tianxia Wu; Heather Hipp; Joan Walter; Michele Scully; Paul A Nyquist; Antonella Bollettino; David Goldman; Mitchell B Max; Thomas J DeGraba Journal: Int J Stroke Date: 2010-06 Impact factor: 5.266
Authors: Helen Kim; Pirro G Hysi; Ludmila Pawlikowska; Annie Poon; Esteban González Burchard; Jonathan G Zaroff; Stephen Sidney; Nerissa U Ko; Achal S Achrol; Michael T Lawton; Charles E McCulloch; Pui-Yan Kwok; William L Young Journal: Cerebrovasc Dis Date: 2008-12-18 Impact factor: 2.762
Authors: Sotirios Tsimikas; Gordon W Duff; Peter B Berger; John Rogus; Kenneth Huttner; Paul Clopton; Emmanuel Brilakis; Kenneth S Kornman; Joseph L Witztum Journal: J Am Coll Cardiol Date: 2014-02-12 Impact factor: 24.094
Authors: S P Balasubramanian; I A F Azmy; S E Higham; A G Wilson; S S Cross; A Cox; N J Brown; M W Reed Journal: BMC Cancer Date: 2006-07-14 Impact factor: 4.430