Literature DB >> 1612768

Morphological changes of cultured endothelial cells after microinjection of toxins that act on the cytoskeleton.

H Müller1, C von Eichel-Streiber, E Habermann.   

Abstract

Clostridium novyi alpha-toxin and C. difficile toxins A and B (all 200 to 300 kDa) and C. botulinum C2-I toxin (50 kDa) caused a delayed and persistent retraction and rounding of microinjected cells. Microinjected phalloidin acted fast and reversibly. Unlike C2-I toxin, phalloidin passed through the intercellular junctions. Specific antitoxin applied to the medium did not prevent the action of microinjected C. novyi or C. difficile toxin B. Microinjected antitoxin protected against the toxins applied with the medium or injected into the same cells.

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Year:  1992        PMID： 1612768      PMCID： PMC257268          DOI： 10.1128/iai.60.7.3007-3010.1992

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  12 in total

1.  Microinjection of alpha-toxin from Clostridium novyi type A promotes meiotic maturation in Xenopus laevis oocytes.

Authors:  P Bette; F Mauler; C Mohr; E Habermann
Journal:  Toxicon       Date:  1990       Impact factor: 3.033

Review 2.  Clostridium difficile toxin A and its effects on cells.

Authors:  C Fiorentini; M Thelestam
Journal:  Toxicon       Date:  1991       Impact factor: 3.033

3.  Lysosomal involvement in cellular intoxication with Clostridium difficile toxin B.

Authors:  I Florin; M Thelestam
Journal:  Microb Pathog       Date:  1986-08       Impact factor: 3.738

4.  Phallotoxins bind to actins.

Authors:  T Wieland; V M Govindan
Journal:  FEBS Lett       Date:  1974-09-15       Impact factor: 4.124

5.  Morphological and biochemical study of cytoskeletal changes in cultured cells after extracellular application of Clostridium novyi alpha-toxin.

Authors:  A Oksche; R Nakov; E Habermann
Journal:  Infect Immun       Date:  1992-07       Impact factor: 3.441

6.  A comparative biochemical, pharmacological and immunological study of Clostridium novyi alpha-toxin, C. difficile toxin B and C. sordellii lethal toxin.

Authors:  P Bette; A Oksche; F Mauler; C von Eichel-Streiber; M R Popoff; E Habermann
Journal:  Toxicon       Date:  1991       Impact factor: 3.033

7.  Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase.

Authors:  W Wiegers; I Just; H Müller; A Hellwig; P Traub; K Aktories
Journal:  Eur J Cell Biol       Date:  1991-04       Impact factor: 4.492

8.  Pharmacological and biochemical studies of cytotoxicity of Clostridium novyi type A alpha-toxin.

Authors:  P Bette; J Frevert; F Mauler; N Suttorp; E Habermann
Journal:  Infect Immun       Date:  1989-08       Impact factor: 3.441

9.  Intercellular junctions and transfer of small molecules in primary vascular endothelial cultures.

Authors:  D M Larson; J D Sheridan
Journal:  J Cell Biol       Date:  1982-01       Impact factor: 10.539

Review 10.  ADP-ribosylation of actin by clostridial toxins.

Authors:  K Aktories; A Wegner
Journal:  J Cell Biol       Date:  1989-10       Impact factor: 10.539
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  6 in total

1.  Microinjection of ADP-ribosylated actin inhibits actin synthesis in hepatocyte-hepatoma hybrid cells.

Authors:  K H Reuner; A van der Does; P Dunker; I Just; K Aktories; N Katz
Journal:  Biochem J       Date:  1996-11-01       Impact factor: 3.857

2.  Purification and characterization of alpha-toxin produced by Clostridium novyi type A.

Authors:  D W Ball; R L Van Tassell; M D Roberts; P E Hahn; D M Lyerly; T D Wilkins
Journal:  Infect Immun       Date:  1993-07       Impact factor: 3.441

3.  Clostridium perfringens epsilon-toxin acts on MDCK cells by forming a large membrane complex.

Authors:  L Petit; M Gibert; D Gillet; C Laurent-Winter; P Boquet; M R Popoff
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

4.  Characterization of the catalytic domain of Clostridium novyi alpha-toxin.

Authors:  C Busch; K Schömig; F Hofmann; K Aktories
Journal:  Infect Immun       Date:  2000-11       Impact factor: 3.441

5.  Sequencing and analysis of the gene encoding the alpha-toxin of Clostridium novyi proves its homology to toxins A and B of Clostridium difficile.

Authors:  F Hofmann; A Herrmann; E Habermann; C von Eichel-Streiber
Journal:  Mol Gen Genet       Date:  1995-06-25

6.  Transient expression of RhoA, -B, and -C GTPases in HeLa cells potentiates resistance to Clostridium difficile toxins A and B but not to Clostridium sordellii lethal toxin.

Authors:  M Giry; M R Popoff; C von Eichel-Streiber; P Boquet
Journal:  Infect Immun       Date:  1995-10       Impact factor: 3.441
  6 in total

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