Literature DB >> 1612767

Morphological and biochemical study of cytoskeletal changes in cultured cells after extracellular application of Clostridium novyi alpha-toxin.

A Oksche1, R Nakov, E Habermann.   

Abstract

Clostridium novyi alpha-toxin caused retraction and rounding of cultured endothelial cells from porcine pulmonary arteries; nevertheless, the endothelial cells firmly adhered to their supports. F-actin stained with fluorescein-labeled phalloidin was condensed around the nucleus, whereas intermediate filaments and microtubules appeared unchanged. The content of F-actin and myosin was decreased, but that of G-actin or vimentin was not. A predominant role of the microfilament system in C. novyi alpha-toxin cytopathic action is suggested.

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Year:  1992        PMID： 1612767      PMCID： PMC257267          DOI： 10.1128/iai.60.7.3002-3006.1992

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  18 in total

Review 1.  Clostridium difficile toxin A and its effects on cells.

Authors:  C Fiorentini; M Thelestam
Journal:  Toxicon       Date:  1991       Impact factor: 3.033

2.  Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium.

Authors:  H J Schnittler; A Wilke; T Gress; N Suttorp; D Drenckhahn
Journal:  J Physiol       Date:  1990-12       Impact factor: 5.182

3.  Effect of Clostridium difficile enterotoxin A on ultrastructure of Chinese hamster ovary cells.

Authors:  V M Kushnaryov; J J Sedmak
Journal:  Infect Immun       Date:  1989-12       Impact factor: 3.441

4.  Effects of Clostridium difficile toxins A and B on cytoskeleton organization in HEp-2 cells: a comparative morphological study.

Authors:  C Fiorentini; G Arancia; S Paradisi; G Donelli; M Giuliano; F Piemonte; P Mastrantonio
Journal:  Toxicon       Date:  1989       Impact factor: 3.033

5.  Biochemical studies on the effect of Clostridium difficile toxin B on actin in vivo and in vitro.

Authors:  M J Mitchell; B E Laughon; S Lin
Journal:  Infect Immun       Date:  1987-07       Impact factor: 3.441

6.  Interaction of Clostridium difficile toxin A with L cells in culture.

Authors:  M S Shahrabadi; L E Bryan; P W Lee
Journal:  Can J Microbiol       Date:  1984-07       Impact factor: 2.419

7.  Studies on the isolation and molecular properties of homogeneous globular actin. Evidence for a single polypeptide chain structure.

Authors:  M K Rees; M Young
Journal:  J Biol Chem       Date:  1967-10-10       Impact factor: 5.157

8.  Pharmacological and biochemical studies of cytotoxicity of Clostridium novyi type A alpha-toxin.

Authors:  P Bette; J Frevert; F Mauler; N Suttorp; E Habermann
Journal:  Infect Immun       Date:  1989-08       Impact factor: 3.441

9.  Clostridium difficile toxin B induces reorganization of actin, vinculin, and talin in cultured cells.

Authors:  M E Ottlinger; S Lin
Journal:  Exp Cell Res       Date:  1988-01       Impact factor: 3.905

10.  Organization of the actin filament cytoskeleton in the intestinal brush border: a quantitative and qualitative immunoelectron microscope study.

Authors:  D Drenckhahn; R Dermietzel
Journal:  J Cell Biol       Date:  1988-09       Impact factor: 10.539
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  5 in total

1.  Purification and characterization of alpha-toxin produced by Clostridium novyi type A.

Authors:  D W Ball; R L Van Tassell; M D Roberts; P E Hahn; D M Lyerly; T D Wilkins
Journal:  Infect Immun       Date:  1993-07       Impact factor: 3.441

2.  Morphological changes of cultured endothelial cells after microinjection of toxins that act on the cytoskeleton.

Authors:  H Müller; C von Eichel-Streiber; E Habermann
Journal:  Infect Immun       Date:  1992-07       Impact factor: 3.441

3.  Sequencing and analysis of the gene encoding the alpha-toxin of Clostridium novyi proves its homology to toxins A and B of Clostridium difficile.

Authors:  F Hofmann; A Herrmann; E Habermann; C von Eichel-Streiber
Journal:  Mol Gen Genet       Date:  1995-06-25

Review 4.  Vaccine Production to Protect Animals Against Pathogenic Clostridia.

Authors:  Nicolas E Zaragoza; Camila A Orellana; Glenn A Moonen; George Moutafis; Esteban Marcellin
Journal:  Toxins (Basel)       Date:  2019-09-11       Impact factor: 4.546

5.  Clostridiumnovyi's Alpha-Toxin Changes Proteome and Phosphoproteome of HEp-2 Cells.

Authors:  Theresa Schweitzer; Harald Genth; Andreas Pich
Journal:  Int J Mol Sci       Date:  2022-09-01       Impact factor: 6.208
  5 in total

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