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Literature DB >> 1612756

Rational attenuation of Corynebacterium pseudotuberculosis: potential cheesy gland vaccine and live delivery vehicle.

A L Hodgson¹, J Krywult, L A Corner, J S Rothel, A J Radford.

Abstract

The phospholipase D (PLD) gene (pld) has been deleted from the Corynebacterium pseudotuberculosis chromosome by using site-specific mutagenesis. Sheep infection trials indicate that the PLD-negative C. pseudotuberculosis strain (Toxminus) is incapable of inducing caseous lymphadentis (cheesy gland) even at doses two logs higher than that at which the wild-type strain produces the disease. This clearly establishes PLD as a major C. pseudotuberculosis virulence factor. Vaccination of sheep with live Toxminus C. pseudotuberculosis elicits strong humoral and cell-mediated immune responses and protects the animals from wild-type challenge.

Entities: Disease Species

Mesh：

Substances：

Year: 1992 PMID： 1612756 PMCID： PMC257252 DOI： 10.1128/iai.60.7.2900-2905.1992

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

21 in total

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22 in total

Review 1. Phospholipase D: enzymology, functionality, and chemical modulation.

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Journal: Chem Rev Date: 2011-09-22 Impact factor: 60.622

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Journal: Clin Microbiol Rev Date: 2000-01 Impact factor: 26.132

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Journal: Infect Immun Date: 1997-08 Impact factor: 3.441

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Journal: Infect Immun Date: 1999-12 Impact factor: 3.441

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Journal: Infect Immun Date: 1994-12 Impact factor: 3.441

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Authors: Jennifer L Edwards; David D Entz; Michael A Apicella
Journal: Infect Immun Date: 2003-11 Impact factor: 3.441